Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1276757..1278171 Replicon chromosome
Accession NZ_CP084625
Organism Pseudomonas lalkuanensis strain ACYW.190

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag LF844_RS06035 Protein ID WP_226283649.1
Coordinates 1276757..1277326 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag LF844_RS06040 Protein ID WP_151132156.1
Coordinates 1277329..1278171 (+) Length 281 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LF844_RS06025 (LF844_06025) 1272496..1272915 + 420 WP_226284370.1 hypothetical protein -
LF844_RS06030 (LF844_06030) 1273026..1276505 - 3480 WP_226283648.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
LF844_RS06035 (LF844_06035) 1276757..1277326 + 570 WP_226283649.1 GNAT family protein Toxin
LF844_RS06040 (LF844_06040) 1277329..1278171 + 843 WP_151132156.1 AraC family transcriptional regulator Antitoxin
LF844_RS06045 (LF844_06045) 1278208..1278939 + 732 WP_151132157.1 AzlC family ABC transporter permease -
LF844_RS06050 (LF844_06050) 1278921..1279250 + 330 WP_151132158.1 AzlD domain-containing protein -
LF844_RS06055 (LF844_06055) 1279473..1281347 + 1875 WP_226283650.1 MFS transporter -
LF844_RS06060 (LF844_06060) 1281392..1281706 - 315 WP_151132160.1 quaternary ammonium compound efflux SMR transporter SugE -
LF844_RS06065 (LF844_06065) 1281886..1282806 - 921 WP_151132161.1 recombination-associated protein RdgC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(14-146)

Antitoxin

DNA binding HTH domain, AraC-type

(194-271)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21373.49 Da        Isoelectric Point: 7.4031

>T218906 WP_226283649.1 NZ_CP084625:1276757-1277326 [Pseudomonas lalkuanensis]
MFNPQPVTLQRGALRLEPLMEADIPALVTLAEANREVLVYMNGPLWPDWYRQALAAQREGRAVVFAIRLGDNLVGTTRFA
DFMPSLPAAEIGWTWLAAGEHGSGLNASIKYLMLRHAFEEWQLVRVQLKTAASNLRSQRAIEKLGAQREGVLRNHRRLAD
GRLDDSVLYSITDHDWPEVRQRLEALFSA

Download         Length: 570 bp

>T218906 NZ_CP116123:c2623046-2622870 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCCATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 281 a.a.        Molecular weight: 31338.49 Da        Isoelectric Point: 7.7446

>AT218906 WP_151132156.1 NZ_CP084625:1277329-1278171 [Pseudomonas lalkuanensis]
VSEQREDAHFWQAGHLDGLELLSARYIEHRFAPHVHDGYVIAVVEAGAERYRYRGVDHLAGAGSLALINPDEVHTGSKGH
DDGWRYRVFYPDVALVRSALEELELPLAGMPAFIGSVHHDPDLVRMFTHLHRLLEANASALEQQTAWREALLALFRRHSR
LPEPGAPGREPLAVLHAKELLRERLAEPPSLEELASAVRLSPFHFARTFRRSTGMPPHAWLKQQRLDQARALLRAGCTPA
GVAAQLGFADQSHLTRQFKQAYGVGPGEYRNACARSFKTH

Download         Length: 843 bp

>AT218906 NZ_CP116123:c2622824-2622408 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATCAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References