Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 228007..228643 Replicon chromosome
Accession NZ_CP084622
Organism Mesobacillus sp. S13

Toxin (Protein)


Gene name mazF Uniprot ID A0A3Q9QS43
Locus tag LGO15_RS01245 Protein ID WP_041967053.1
Coordinates 228293..228643 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID W4RP20
Locus tag LGO15_RS01240 Protein ID WP_031308192.1
Coordinates 228007..228288 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGO15_RS01220 224067..224651 - 585 WP_226086391.1 rhomboid family intramembrane serine protease -
LGO15_RS01225 224821..225174 + 354 WP_226086392.1 holo-ACP synthase -
LGO15_RS01230 225366..226379 + 1014 WP_226086393.1 outer membrane lipoprotein carrier protein LolA -
LGO15_RS01235 226656..227813 + 1158 WP_226086394.1 alanine racemase -
LGO15_RS01240 228007..228288 + 282 WP_031308192.1 hypothetical protein Antitoxin
LGO15_RS01245 228293..228643 + 351 WP_041967053.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
LGO15_RS01250 229349..230182 + 834 WP_167834257.1 RsbT co-antagonist protein RsbRA -
LGO15_RS01255 230179..230535 + 357 WP_041967776.1 STAS domain-containing protein -
LGO15_RS01260 230540..230941 + 402 WP_041967777.1 anti-sigma regulatory factor -
LGO15_RS01265 230953..231963 + 1011 WP_167834256.1 PP2C family protein-serine/threonine phosphatase -
LGO15_RS01270 232021..232353 + 333 WP_167834255.1 anti-sigma factor antagonist -
LGO15_RS01275 232350..232823 + 474 WP_167834254.1 anti-sigma B factor RsbW -
LGO15_RS01280 232801..233595 + 795 WP_144481156.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13020.06 Da        Isoelectric Point: 4.8998

>T218905 WP_041967053.1 NZ_CP084622:228293-228643 [Mesobacillus sp. S13]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLGLIEF

Download         Length: 351 bp

>T218905 NZ_CP116123:2517960-2519282 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAATGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAACCGTTATGCCAGACCGTTATCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
TGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTGCCGGACGCAGAAATCATTAAAGCGGGGAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTGTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCGCAGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGGTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTTCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGCCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10753.28 Da        Isoelectric Point: 7.2035

>AT218905 WP_031308192.1 NZ_CP084622:228007-228288 [Mesobacillus sp. S13]
VSESSATTEILVKLPQHLLSELDGFVKQENVNRSEFIYQATKMFLREKKKRQIRESMRRGYMEMAKINLTIASEAFQAEY
EAEHTVERLVSGG

Download         Length: 282 bp

>AT218905 NZ_CP116123:2517694-2517960 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGTCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TGACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q9QS43

Antitoxin

Source ID Structure
AlphaFold DB W4RP20

References