Detailed information of TA system TA218903

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 15524..16080
• Replicon: plasmid unnamed2
• Accession: NZ_CP084594
• Organism: Mycobacterium intracellulare subsp. chimaera strain 850

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LFT51_RS28955
• Protein ID: WP_046182242.1
• Coordinates: 15524..15799 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LFT51_RS28960
• Protein ID: WP_082122855.1
• Coordinates: 15796..16080 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LFT51_RS28930 (LFT51_28930)	11706..12677	-	972	WP_226069303.1	fatty acid desaturase	-
LFT51_RS28935 (LFT51_28935)	12896..13648	-	753	WP_172417609.1	1-aminocyclopropane-1-carboxylate synthase	-
LFT51_RS28940 (LFT51_28940)	14124..14690	-	567	WP_046182262.1	recombinase family protein	-
LFT51_RS28945 (LFT51_28945)	14839..15114	-	276	WP_046182244.1	hypothetical protein	-
LFT51_RS28950 (LFT51_28950)	15191..15406	+	216	WP_046182243.1	hypothetical protein	-
LFT51_RS28955 (LFT51_28955)	15524..15799	-	276	WP_046182242.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LFT51_RS28960 (LFT51_28960)	15796..16080	-	285	WP_082122855.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LFT51_RS28965 (LFT51_28965)	16309..16698	-	390	Protein_9	pyridoxamine 5'-phosphate oxidase family protein	-
LFT51_RS28970 (LFT51_28970)	16767..17564	-	798	WP_046182240.1	sigma 54 modulation/S30EA ribosomal C-terminal domain-containing protein	-
LFT51_RS28975 (LFT51_28975)	17709..20543	-	2835	WP_054585406.1	MobF family relaxase	-
LFT51_RS28980 (LFT51_28980)	20779..21033	+	255	WP_142383129.1	antitoxin VbhA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..39887	39887

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (4-74)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10459.92 Da
• Isoelectric Point: 10.0890

>T218903 WP_046182242.1 NZ_CP084594:c15799-15524 [Mycobacterium intracellulare subsp. chimaera]
VTDRRYELIIAPTAKKQLAEQLPESAAFAAYEFIIGPLLDNPHRVGKQLRPPLHDRHSARRGTYRVLYRIDDERQQVTVV
GVFSRADAYRA

Nucleotide

• Length: 276 bp

>T218903 NZ_CP116123:1222809-1223120 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCTAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 9876.02 Da
• Isoelectric Point: 4.4269

>AT218903 WP_082122855.1 NZ_CP084594:c16080-15796 [Mycobacterium intracellulare subsp. chimaera]
MSEVSSLAEAKAHLSELVARVGDQHERITVTVHGRPAAVLLAVDDLESLEETIAVLSDAAALRALAEADAELARGEGENQ
DSLSAAMQARRAKT

Nucleotide

• Length: 285 bp

>AT218903 NZ_CP116123:1223117-1223536 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCCTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCATATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA