Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 82503..83185 Replicon plasmid unnamed1
Accession NZ_CP084593
Organism Mycobacterium intracellulare subsp. chimaera strain 850

Toxin (Protein)


Gene name vapC Uniprot ID A0A854IDQ2
Locus tag LFT51_RS28860 Protein ID WP_040624374.1
Coordinates 82503..82919 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5P579
Locus tag LFT51_RS28865 Protein ID WP_007172349.1
Coordinates 82922..83185 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFT51_RS28840 (LFT51_28840) 78270..78408 - 139 Protein_85 type II toxin-antitoxin system VapC family toxin -
LFT51_RS28845 (LFT51_28845) 78514..80166 - 1653 WP_040624340.1 IS607 family element RNA-guided endonuclease TnpB -
LFT51_RS28850 (LFT51_28850) 80166..80747 - 582 WP_007172352.1 IS607 family transposase -
LFT51_RS28855 (LFT51_28855) 80890..82221 + 1332 WP_023363507.1 IS256 family transposase -
LFT51_RS28860 (LFT51_28860) 82503..82919 - 417 WP_040624374.1 type II toxin-antitoxin system VapC family toxin Toxin
LFT51_RS28865 (LFT51_28865) 82922..83185 - 264 WP_007172349.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LFT51_RS28870 (LFT51_28870) 83398..84261 + 864 WP_142383462.1 hypothetical protein -
LFT51_RS28875 (LFT51_28875) 84685..85428 + 744 WP_225336958.1 hypothetical protein -
LFT51_RS28880 (LFT51_28880) 85514..86554 + 1041 WP_023363502.1 C40 family peptidase -
LFT51_RS28885 (LFT51_28885) 86578..88113 + 1536 WP_225336956.1 type VII secretion protein EccB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - eccA5 / esxN 1..97267 97267


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(1-82)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14879.84 Da        Isoelectric Point: 5.4519

>T218902 WP_040624374.1 NZ_CP084593:c82919-82503 [Mycobacterium intracellulare subsp. chimaera]
MIIDSSAIVALIQGEDPYTEQIAAAIAADPSPVMSTANAAECLIVLTNRHGATARTVFDRLRSEINLGFQPFTLEHAIAA
HRAYLHYGKGRHPAALNYGDTMAYATAKLAHEPLIAIGNDFTQTDLEFNGVIGYWPAP

Download         Length: 417 bp

>T218902 NZ_CP116123:1148575-1148910 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9884.20 Da        Isoelectric Point: 4.8359

>AT218902 WP_007172349.1 NZ_CP084593:c83185-82922 [Mycobacterium intracellulare subsp. chimaera]
MAFNVKDEEVIRFADELAARLHLPSRIDAIRYALRAQIEVTQSRTANRSAELLDVLKTEIWPLLDDRSPITKTEREQALG
YDTATGV

Download         Length: 264 bp

>AT218902 NZ_CP116123:1148327-1148575 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854IDQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Y0TBQ2

References