Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 69929..70470 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP084593 | ||
| Organism | Mycobacterium intracellulare subsp. chimaera strain 850 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | D5P595 |
| Locus tag | LFT51_RS28795 | Protein ID | WP_007172365.1 |
| Coordinates | 70177..70470 (+) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A854I1S2 |
| Locus tag | LFT51_RS28790 | Protein ID | WP_040624378.1 |
| Coordinates | 69929..70180 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LFT51_RS28765 (LFT51_28765) | 65441..67303 | - | 1863 | WP_023363516.1 | helicase associated domain-containing protein | - |
| LFT51_RS28770 (LFT51_28770) | 67680..67964 | - | 285 | WP_007172369.1 | hypothetical protein | - |
| LFT51_RS28775 (LFT51_28775) | 67927..68517 | - | 591 | WP_023363514.1 | hypothetical protein | - |
| LFT51_RS28780 (LFT51_28780) | 68573..69010 | - | 438 | WP_007172368.1 | WhiB family transcriptional regulator | - |
| LFT51_RS28785 (LFT51_28785) | 69317..69823 | + | 507 | WP_007172367.1 | helix-turn-helix transcriptional regulator | - |
| LFT51_RS28790 (LFT51_28790) | 69929..70180 | + | 252 | WP_040624378.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| LFT51_RS28795 (LFT51_28795) | 70177..70470 | + | 294 | WP_007172365.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LFT51_RS28800 (LFT51_28800) | 70688..71395 | + | 708 | WP_139315443.1 | hypothetical protein | - |
| LFT51_RS28805 (LFT51_28805) | 71409..72107 | + | 699 | WP_139315442.1 | hypothetical protein | - |
| LFT51_RS28810 (LFT51_28810) | 72222..73301 | + | 1080 | WP_007172361.1 | DUF6036 family nucleotidyltransferase | - |
| LFT51_RS28815 (LFT51_28815) | 73411..74082 | + | 672 | WP_139315441.1 | hypothetical protein | - |
| LFT51_RS28820 (LFT51_28820) | 74206..74478 | + | 273 | WP_139315440.1 | hypothetical protein | - |
| LFT51_RS28825 (LFT51_28825) | 74709..75140 | + | 432 | WP_139315439.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | eccA5 / esxN | 1..97267 | 97267 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11261.74 Da Isoelectric Point: 6.9772
>T218901 WP_007172365.1 NZ_CP084593:70177-70470 [Mycobacterium intracellulare subsp. chimaera]
VSAYVLSPAAQADLEQIWDYTHEHWGLDQAEQYLRELQRAIERAAANPRIGRACDEIRPGYRKLAAGSHMLFYRVTTQGF
LDVVRVLHQRMDVDRHL
VSAYVLSPAAQADLEQIWDYTHEHWGLDQAEQYLRELQRAIERAAANPRIGRACDEIRPGYRKLAAGSHMLFYRVTTQGF
LDVVRVLHQRMDVDRHL
Download Length: 294 bp
>T218901 NZ_CP116123:1002648-1003055 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9203.22 Da Isoelectric Point: 5.8579
>AT218901 WP_040624378.1 NZ_CP084593:69929-70180 [Mycobacterium intracellulare subsp. chimaera]
VGKNTSFSLDEHYSAFIEAEVAAGRYRSASDVVRSALRLLEDREIQLRALREALVAGERSGTSTPFDFDAFLDGKRAEKP
QGR
VGKNTSFSLDEHYSAFIEAEVAAGRYRSASDVVRSALRLLEDREIQLRALREALVAGERSGTSTPFDFDAFLDGKRAEKP
QGR
Download Length: 252 bp
>AT218901 NZ_CP116123:1002401-1002667 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTTTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTTTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1Y0TBP0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A854I1S2 |