Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-ParD |
| Location | 2944389..2945381 | Replicon | chromosome |
| Accession | NZ_CP084592 | ||
| Organism | Mycobacterium intracellulare subsp. chimaera strain 850 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | A0A854HPC2 |
| Locus tag | LFT51_RS13790 | Protein ID | WP_054585353.1 |
| Coordinates | 2944803..2945381 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | A0A854UQX7 |
| Locus tag | LFT51_RS13785 | Protein ID | WP_054585352.1 |
| Coordinates | 2944389..2944778 (+) | Length | 130 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LFT51_RS13765 (LFT51_13765) | 2939540..2940208 | - | 669 | WP_179300141.1 | hypothetical protein | - |
| LFT51_RS13770 (LFT51_13770) | 2940288..2941805 | + | 1518 | WP_054585349.1 | carboxylesterase/lipase family protein | - |
| LFT51_RS13775 (LFT51_13775) | 2941824..2943827 | + | 2004 | WP_054585350.1 | phosphotransferase | - |
| LFT51_RS13780 (LFT51_13780) | 2943824..2944318 | + | 495 | WP_054585351.1 | gluconokinase | - |
| LFT51_RS13785 (LFT51_13785) | 2944389..2944778 | + | 390 | WP_054585352.1 | hypothetical protein | Antitoxin |
| LFT51_RS13790 (LFT51_13790) | 2944803..2945381 | + | 579 | WP_054585353.1 | zeta toxin family protein | Toxin |
| LFT51_RS13795 (LFT51_13795) | 2945392..2946459 | - | 1068 | WP_054585354.1 | DoxX family protein | - |
| LFT51_RS13800 (LFT51_13800) | 2946555..2947115 | + | 561 | WP_008256422.1 | pyrazinamidase PncA | - |
| LFT51_RS13805 (LFT51_13805) | 2947115..2947915 | + | 801 | WP_054585355.1 | nuclear transport factor 2 family protein | - |
| LFT51_RS13810 (LFT51_13810) | 2947927..2948277 | - | 351 | WP_054585356.1 | DoxX family protein | - |
| LFT51_RS13815 (LFT51_13815) | 2948443..2949414 | + | 972 | WP_054585357.1 | sigma-70 family RNA polymerase sigma factor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21127.16 Da Isoelectric Point: 10.7751
>T218898 WP_054585353.1 NZ_CP084592:2944803-2945381 [Mycobacterium intracellulare subsp. chimaera]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPEESAGRAYDAAQIAADTRAKLIDLGRSFIAETVFSH
PSKLDLIRTAHRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNSRLRG
PRIVARLTGGMTIGSPDWPAWTPGTLRSRWAD
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPEESAGRAYDAAQIAADTRAKLIDLGRSFIAETVFSH
PSKLDLIRTAHRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNSRLRG
PRIVARLTGGMTIGSPDWPAWTPGTLRSRWAD
Download Length: 579 bp
>T218898 NZ_CP116123:c668105-667641 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAGCCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAGCCCATTGA
Antitoxin
Download Length: 130 a.a. Molecular weight: 13529.94 Da Isoelectric Point: 5.5559
>AT218898 WP_054585352.1 NZ_CP084592:2944389-2944778 [Mycobacterium intracellulare subsp. chimaera]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAAMAGQLATGELTVEEGVVFNAEI
SAAIEESLVHANYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAAMAGQLATGELTVEEGVVFNAEI
SAAIEESLVHANYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR
Download Length: 390 bp
>AT218898 NZ_CP116123:c668440-668105 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACACTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACACTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A854HPC2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A854UQX7 |