Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 2613305..2613969 Replicon chromosome
Accession NZ_CP084592
Organism Mycobacterium intracellulare subsp. chimaera strain 850

Toxin (Protein)


Gene name vapC Uniprot ID J9WD27
Locus tag LFT51_RS12350 Protein ID WP_009954498.1
Coordinates 2613562..2613969 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LFT51_RS12345 Protein ID WP_009954496.1
Coordinates 2613305..2613565 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFT51_RS12320 (LFT51_12320) 2609814..2610305 - 492 WP_014711439.1 DUF1707 domain-containing protein -
LFT51_RS12325 (LFT51_12325) 2610375..2610971 + 597 WP_042911492.1 TetR/AcrR family transcriptional regulator -
LFT51_RS12330 (LFT51_12330) 2610976..2612244 - 1269 WP_042911493.1 cytochrome P450 -
LFT51_RS12335 (LFT51_12335) 2612402..2612854 + 453 WP_042911495.1 VOC family protein -
LFT51_RS12340 (LFT51_12340) 2612925..2613182 + 258 WP_042911496.1 hypothetical protein -
LFT51_RS12345 (LFT51_12345) 2613305..2613565 + 261 WP_009954496.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LFT51_RS12350 (LFT51_12350) 2613562..2613969 + 408 WP_009954498.1 type II toxin-antitoxin system VapC family toxin Toxin
LFT51_RS12355 (LFT51_12355) 2614147..2617248 + 3102 WP_042911498.1 DEAD/DEAH box helicase -
LFT51_RS12360 (LFT51_12360) 2617310..2618875 - 1566 WP_042911499.1 serine/threonine-protein kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-66)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14293.28 Da        Isoelectric Point: 4.2772

>T218897 WP_009954498.1 NZ_CP084592:2613562-2613969 [Mycobacterium intracellulare subsp. chimaera]
MSNPQVAGVLDTSVFIATESGRPLDAALIPDQVGTTVVTLAELHVGVLAASTSDIRAQRLATLESIADIEALPVDDDAAR
MWARLRIHLAETGQRVRINDLWIAAIAASRGLPVVTQDDDFAVLDGAANLTVIRV

Download         Length: 408 bp

>T218897 NZ_CP116123:255084-255191 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9526.85 Da        Isoelectric Point: 9.1203

>AT218897 WP_009954496.1 NZ_CP084592:2613305-2613565 [Mycobacterium intracellulare subsp. chimaera]
MSEVASRELRNDTAGVLRRVRDGEDVTITVSGRPVAVLTAVVPQRRRWLSKTELLSRLPRVQADPGLREDLHALAGDTTE
ELGPIR

Download         Length: 261 bp

>AT218897 NZ_CP116123:c255035-254972 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J9WD27

Antitoxin

Source ID Structure

References