Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1601663..1602225 Replicon chromosome
Accession NZ_CP084592
Organism Mycobacterium intracellulare subsp. chimaera strain 850

Toxin (Protein)


Gene name vapC Uniprot ID A0A081I0A5
Locus tag LFT51_RS07990 Protein ID WP_036454801.1
Coordinates 1601857..1602225 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A081I0A4
Locus tag LFT51_RS07985 Protein ID WP_036455532.1
Coordinates 1601663..1601860 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFT51_RS07950 (LFT51_07950) 1596767..1597912 - 1146 WP_179945068.1 hypothetical protein -
LFT51_RS07955 (LFT51_07955) 1598042..1599115 + 1074 WP_042910932.1 redox-regulated ATPase YchF -
LFT51_RS07960 (LFT51_07960) 1599147..1599872 + 726 WP_051445843.1 aminoglycoside 3'-phosphotransferase -
LFT51_RS07965 (LFT51_07965) 1599960..1600244 + 285 WP_020821851.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LFT51_RS07970 (LFT51_07970) 1600259..1600504 + 246 WP_042910934.1 type II toxin-antitoxin system RelE/ParE family toxin -
LFT51_RS07975 (LFT51_07975) 1600540..1601091 + 552 WP_036454798.1 VOC family protein -
LFT51_RS07980 (LFT51_07980) 1601170..1601568 + 399 WP_036454800.1 VOC family protein -
LFT51_RS07985 (LFT51_07985) 1601663..1601860 + 198 WP_036455532.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LFT51_RS07990 (LFT51_07990) 1601857..1602225 + 369 WP_036454801.1 type II toxin-antitoxin system VapC family toxin Toxin
LFT51_RS07995 (LFT51_07995) 1602408..1602749 + 342 WP_172417493.1 hypothetical protein -
LFT51_RS08000 (LFT51_08000) 1602835..1603194 + 360 WP_042910935.1 hypothetical protein -
LFT51_RS08005 (LFT51_08005) 1603379..1603954 + 576 WP_075630262.1 C40 family peptidase -
LFT51_RS08010 (LFT51_08010) 1604317..1604640 + 324 WP_036454806.1 putative quinol monooxygenase -
LFT51_RS08015 (LFT51_08015) 1604678..1605511 - 834 WP_036454808.1 SAM-dependent methyltransferase -
LFT51_RS08020 (LFT51_08020) 1605546..1606229 - 684 WP_036455537.1 hypothetical protein -
LFT51_RS08025 (LFT51_08025) 1606376..1606585 + 210 WP_072501223.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13435.74 Da        Isoelectric Point: 6.4862

>T218895 WP_036454801.1 NZ_CP084592:1601857-1602225 [Mycobacterium intracellulare subsp. chimaera]
MILVDTAVWIDHLHTAELRLVKLLEIDQVGCHALVIEELALGSISRREVVLDLLANLRQFPTVQHAEILHLTGQRKLYGR
GLSAVDVHLMAAVALVEGAQLWTRDKRLKAASVDAGIALFDA

Download         Length: 369 bp

>T218895 NZ_CP116123:254117-254224 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6871.88 Da        Isoelectric Point: 11.6072

>AT218895 WP_036455532.1 NZ_CP084592:1601663-1601860 [Mycobacterium intracellulare subsp. chimaera]
MRTTVTIDDDLLAKAAELTGVRENVALLREGLQTLIRVESARRLAALGGTDAGAVAAPRRRRGTG

Download         Length: 198 bp

>AT218895 NZ_CP116123:c254059-254005 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A081I0A5

Antitoxin

Source ID Structure
AlphaFold DB A0A081I0A4

References