Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1599960..1600504 Replicon chromosome
Accession NZ_CP084592
Organism Mycobacterium intracellulare subsp. chimaera strain 850

Toxin (Protein)


Gene name relE Uniprot ID A0A854HUL3
Locus tag LFT51_RS07970 Protein ID WP_042910934.1
Coordinates 1600259..1600504 (+) Length 82 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S4Z4W6
Locus tag LFT51_RS07965 Protein ID WP_020821851.1
Coordinates 1599960..1600244 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFT51_RS07940 (LFT51_07940) 1595034..1595633 - 600 WP_009953444.1 lipid droplet-associated protein -
LFT51_RS07945 (LFT51_07945) 1595723..1596721 + 999 WP_042910931.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
LFT51_RS07950 (LFT51_07950) 1596767..1597912 - 1146 WP_179945068.1 hypothetical protein -
LFT51_RS07955 (LFT51_07955) 1598042..1599115 + 1074 WP_042910932.1 redox-regulated ATPase YchF -
LFT51_RS07960 (LFT51_07960) 1599147..1599872 + 726 WP_051445843.1 aminoglycoside 3'-phosphotransferase -
LFT51_RS07965 (LFT51_07965) 1599960..1600244 + 285 WP_020821851.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LFT51_RS07970 (LFT51_07970) 1600259..1600504 + 246 WP_042910934.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LFT51_RS07975 (LFT51_07975) 1600540..1601091 + 552 WP_036454798.1 VOC family protein -
LFT51_RS07980 (LFT51_07980) 1601170..1601568 + 399 WP_036454800.1 VOC family protein -
LFT51_RS07985 (LFT51_07985) 1601663..1601860 + 198 WP_036455532.1 type II toxin-antitoxin system VapB family antitoxin -
LFT51_RS07990 (LFT51_07990) 1601857..1602225 + 369 WP_036454801.1 type II toxin-antitoxin system VapC family toxin -
LFT51_RS07995 (LFT51_07995) 1602408..1602749 + 342 WP_172417493.1 hypothetical protein -
LFT51_RS08000 (LFT51_08000) 1602835..1603194 + 360 WP_042910935.1 hypothetical protein -
LFT51_RS08005 (LFT51_08005) 1603379..1603954 + 576 WP_075630262.1 C40 family peptidase -
LFT51_RS08010 (LFT51_08010) 1604317..1604640 + 324 WP_036454806.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(29-80)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9380.95 Da        Isoelectric Point: 11.2612

>T218894 WP_042910934.1 NZ_CP084592:1600259-1600504 [Mycobacterium intracellulare subsp. chimaera]
MTAAAKRALTHLLPESVAIACWEFIRGPLAENPQRVGKPLRGQLEGRYSARRGEFRVIYRIFDERVVVPVIHIAHRRDVY
R

Download         Length: 246 bp

>T218894 NZ_CP116123:198432-198617 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10513.88 Da        Isoelectric Point: 4.3705

>AT218894 WP_020821851.1 NZ_CP084592:1599960-1600244 [Mycobacterium intracellulare subsp. chimaera]
MSTLPLAEVRANLSKLVDEAVRTHERIEVTRQGRRAAVILSADDFDSIMETLAILSDQDLMREVRAAESEAEDGALYTLD
QVTEEMRAVGRLPR

Download         Length: 285 bp

>AT218894 NZ_CP116123:198634-199044 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGTGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGGTTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCAGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854HUL3

Antitoxin

Source ID Structure
AlphaFold DB S4Z4W6

References