Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PHD(antitoxin) |
| Location | 1136698..1137381 | Replicon | chromosome |
| Accession | NZ_CP084592 | ||
| Organism | Mycobacterium intracellulare subsp. chimaera strain 850 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | D5PEA4 |
| Locus tag | LFT51_RS05695 | Protein ID | WP_007168487.1 |
| Coordinates | 1136698..1137105 (-) | Length | 136 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A1X1XBB9 |
| Locus tag | LFT51_RS05700 | Protein ID | WP_033711258.1 |
| Coordinates | 1137109..1137381 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LFT51_RS05655 (LFT51_05655) | 1131922..1132321 | + | 400 | Protein_1116 | replicative DNA helicase | - |
| LFT51_RS05660 (LFT51_05660) | 1132345..1132593 | + | 249 | Protein_1117 | transposase | - |
| LFT51_RS05665 (LFT51_05665) | 1132750..1133934 | + | 1185 | WP_040624521.1 | IS30 family transposase | - |
| LFT51_RS05670 (LFT51_05670) | 1134036..1134188 | - | 153 | WP_007168480.1 | enoyl-CoA hydratase-related protein | - |
| LFT51_RS05675 (LFT51_05675) | 1134264..1134356 | - | 93 | Protein_1120 | ATPase | - |
| LFT51_RS05680 (LFT51_05680) | 1134379..1134522 | + | 144 | WP_155250266.1 | hypothetical protein | - |
| LFT51_RS05685 (LFT51_05685) | 1135970..1136275 | - | 306 | WP_007168485.1 | hypothetical protein | - |
| LFT51_RS05690 (LFT51_05690) | 1136336..1136677 | - | 342 | WP_007168486.1 | hypothetical protein | - |
| LFT51_RS05695 (LFT51_05695) | 1136698..1137105 | - | 408 | WP_007168487.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LFT51_RS05700 (LFT51_05700) | 1137109..1137381 | - | 273 | WP_033711258.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| LFT51_RS05705 (LFT51_05705) | 1137877..1139112 | - | 1236 | WP_042909886.1 | IS256 family transposase | - |
| LFT51_RS05710 (LFT51_05710) | 1139754..1139939 | + | 186 | WP_132160383.1 | hypothetical protein | - |
| LFT51_RS05715 (LFT51_05715) | 1140013..1140429 | - | 417 | WP_007168492.1 | type II toxin-antitoxin system VapC family toxin | - |
| LFT51_RS05720 (LFT51_05720) | 1140426..1140677 | - | 252 | WP_007168493.1 | ribbon-helix-helix protein, CopG family | - |
| LFT51_RS05725 (LFT51_05725) | 1141479..1141874 | + | 396 | WP_007168495.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1137877..1139112 | 1235 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 14464.55 Da Isoelectric Point: 4.6697
>T218892 WP_007168487.1 NZ_CP084592:c1137105-1136698 [Mycobacterium intracellulare subsp. chimaera]
VIYLDTSALVKLIRIEVESDALADWLDERTETRWITSALAEVELPRAIRAVAPNGLSAVPSVLARLDRFEIDQVIRATAA
AYPDPALRSLDAIHLATAQIAASTAPLTAMVAYDSRLSDAARALGITIVTPGRNS
VIYLDTSALVKLIRIEVESDALADWLDERTETRWITSALAEVELPRAIRAVAPNGLSAVPSVLARLDRFEIDQVIRATAA
AYPDPALRSLDAIHLATAQIAASTAPLTAMVAYDSRLSDAARALGITIVTPGRNS
Download Length: 408 bp
>T218892 NZ_CP116118:55303-55719 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 9764.35 Da Isoelectric Point: 8.7382
>AT218892 WP_033711258.1 NZ_CP084592:c1137381-1137109 [Mycobacterium intracellulare subsp. chimaera]
MSEVPLRMLNQETAKVLARVKRGEEITLTERGEVIARIIPATAGPLDALITAGRVQPATLAGPAPRPTVPMHDNLDAGAL
LQRLRAEERY
MSEVPLRMLNQETAKVLARVKRGEEITLTERGEVIARIIPATAGPLDALITAGRVQPATLAGPAPRPTVPMHDNLDAGAL
LQRLRAEERY
Download Length: 273 bp
>AT218892 NZ_CP116118:55076-55306 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1X1XAJ9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1X1XBB9 |