Detailed information of TA system TA218891

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 1071744..1072411
• Replicon: chromosome
• Accession: NZ_CP084592
• Organism: Mycobacterium intracellulare subsp. chimaera strain 850

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: D5PE24
• Locus tag: LFT51_RS05345
• Protein ID: WP_007168407.1
• Coordinates: 1072019..1072411 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: D5PE23
• Locus tag: LFT51_RS05340
• Protein ID: WP_007168406.1
• Coordinates: 1071744..1072019 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LFT51_RS05310 (LFT51_05310)	1067564..1067797	-	234	Protein_1047	transposase	-
LFT51_RS05315 (LFT51_05315)	1067866..1068978	-	1113	Protein_1048	ISL3 family transposase	-
LFT51_RS05320 (LFT51_05320)	1069150..1069794	-	645	WP_019731991.1	DDE-type integrase/transposase/recombinase	-
LFT51_RS05330 (LFT51_05330)	1069933..1070636	-	704	Protein_1050	phosphoglycerate mutase family protein	-
LFT51_RS05335 (LFT51_05335)	1070719..1071591	+	873	WP_007168405.1	MaoC/PaaZ C-terminal domain-containing protein	-
LFT51_RS05340 (LFT51_05340)	1071744..1072019	+	276	WP_007168406.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LFT51_RS05345 (LFT51_05345)	1072019..1072411	+	393	WP_007168407.1	type II toxin-antitoxin system VapC family toxin	Toxin
LFT51_RS05350 (LFT51_05350)	1072559..1073718	-	1160	Protein_1054	trehalose-phosphatase	-
LFT51_RS05355 (LFT51_05355)	1073760..1075098	-	1339	Protein_1055	WS/DGAT domain-containing protein	-
LFT51_RS05360 (LFT51_05360)	1075258..1075482	-	225	Protein_1056	IS1595 family transposase	-
LFT51_RS05365 (LFT51_05365)	1075743..1077152	+	1410	Protein_1057	IS1182 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1067248..1133934	66686

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-119)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-45)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14305.73 Da
• Isoelectric Point: 10.5032

>T218891 WP_007168407.1 NZ_CP084592:1072019-1072411 [Mycobacterium intracellulare subsp. chimaera]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRLPRVSSALARTEVMRALLHKGESARRAGRRALASLDLLRIDNRLLDLAG
GLLPIELRTLDAIHLATAQRLGMDLGRLCTYDDRMRDAAEALGMAVIAPS

Nucleotide

• Length: 393 bp

>T218891 NZ_CP116118:50440-50856 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10150.63 Da
• Isoelectric Point: 5.1881

>AT218891 WP_007168406.1 NZ_CP084592:1071744-1072019 [Mycobacterium intracellulare subsp. chimaera]
MSTVGVRELRQRASELLRRVEAGETIEITDRGRPIALLSPMPEGGPYQQMLASGGIERATLDFDDLPEPVRLKTGIELPS
VTLARLREHER

Nucleotide

• Length: 276 bp

>AT218891 NZ_CP116118:50213-50443 [Escherichia coli]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA

Structures

Toxin

• AlphaFold DB: A0A1X1XV84

Antitoxin

• AlphaFold DB: A0A1X1XUZ3