Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 863802..864331 Replicon chromosome
Accession NZ_CP084592
Organism Mycobacterium intracellulare subsp. chimaera strain 850

Toxin (Protein)


Gene name Rv0299 Uniprot ID X7VD93
Locus tag LFT51_RS04400 Protein ID WP_007172144.1
Coordinates 863802..864107 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID A0A1X1WNE2
Locus tag LFT51_RS04405 Protein ID WP_042910679.1
Coordinates 864104..864331 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFT51_RS04370 (LFT51_04370) 858880..859020 + 141 WP_007172137.1 hypothetical protein -
LFT51_RS04375 (LFT51_04375) 859017..859403 + 387 WP_007172138.1 YbaB/EbfC family nucleoid-associated protein -
LFT51_RS04380 (LFT51_04380) 859473..860150 + 678 WP_101930854.1 hypothetical protein -
LFT51_RS04385 (LFT51_04385) 860150..860482 + 333 WP_033717256.1 hypothetical protein -
LFT51_RS04390 (LFT51_04390) 860770..861057 + 288 WP_007172141.1 hypothetical protein -
LFT51_RS04395 (LFT51_04395) 861076..863430 + 2355 WP_007172142.1 hypothetical protein -
LFT51_RS04400 (LFT51_04400) 863802..864107 - 306 WP_007172144.1 hypothetical protein Toxin
LFT51_RS04405 (LFT51_04405) 864104..864331 - 228 WP_042910679.1 ribbon-helix-helix protein, CopG family Antitoxin
LFT51_RS04410 (LFT51_04410) 864467..864639 + 173 Protein_864 type II toxin-antitoxin system prevent-host-death family antitoxin -
LFT51_RS04415 (LFT51_04415) 864817..866307 + 1491 WP_007172147.1 type VII secretion protein EccB -
LFT51_RS04420 (LFT51_04420) 866381..867436 + 1056 WP_007172148.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 10428.23 Da        Isoelectric Point: 3.9382

>T218890 WP_007172144.1 NZ_CP084592:c864107-863802 [Mycobacterium intracellulare subsp. chimaera]
VITPGDITPGRDTNQELYVVVLSNTIHLAAATGQVIICPFIPGEIPSSTMAMIVTVLQPKGVVLPELIQWLPVAALDQPI
GNIGGIALADTTTTAVTALIS

Download         Length: 306 bp

>T218890 NZ_CP116118:c46029-45724 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8167.24 Da        Isoelectric Point: 5.0079

>AT218890 WP_042910679.1 NZ_CP084592:c864331-864104 [Mycobacterium intracellulare subsp. chimaera]
MAKAKVSVMIEEAVLAAADADAQAAGLNRSEMIERALHNEHLRISLENYTTHTVPTLDIDAYAEKIYQANRAAGL

Download         Length: 228 bp

>AT218890 NZ_CP116118:c46249-46031 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XDZ0

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1WNE2

References