Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2894516..2895230 Replicon chromosome
Accession NC_008769
Organism Mycobacterium bovis BCG str. Pasteur 1173P2

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag BCG_RS13560 Protein ID WP_003413460.1
Coordinates 2894790..2895230 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag BCG_RS13555 Protein ID WP_003413456.1
Coordinates 2894516..2894803 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCG_RS13520 2889948..2890193 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
BCG_RS13525 2890190..2890594 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
BCG_RS13530 2890811..2891431 + 621 WP_003413441.1 DUF4178 domain-containing protein -
BCG_RS13535 2891442..2891936 + 495 WP_003413444.1 DUF2617 family protein -
BCG_RS13540 2891933..2892364 + 432 WP_003413445.1 DUF4247 domain-containing protein -
BCG_RS13545 2892389..2892837 + 449 Protein_2639 DUF350 domain-containing protein -
BCG_RS13550 2892834..2894405 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
BCG_RS13555 2894516..2894803 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
BCG_RS13560 2894790..2895230 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
BCG_RS13565 2895251..2896006 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
BCG_RS13570 2896139..2896735 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
BCG_RS13575 2896743..2897588 - 846 WP_010950749.1 acyl-CoA thioesterase II -
BCG_RS13580 2897617..2898516 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
BCG_RS13585 2898644..2899318 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T21889 WP_003413460.1 NC_008769:2894790-2895230 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T21889 NC_008769:2894790-2895230 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT21889 WP_003413456.1 NC_008769:2894516-2894803 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT21889 NC_008769:2894516-2894803 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References