Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 287538..288436 Replicon chromosome
Accession NZ_CP084592
Organism Mycobacterium intracellulare subsp. chimaera strain 850

Toxin (Protein)


Gene name mbcT Uniprot ID A0A7I9ZD82
Locus tag LFT51_RS01405 Protein ID WP_042910420.1
Coordinates 287538..288098 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID A0A7I9ZDJ0
Locus tag LFT51_RS01410 Protein ID WP_042910421.1
Coordinates 288095..288436 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFT51_RS01385 (LFT51_01385) 284418..284903 + 486 WP_051445817.1 hypothetical protein -
LFT51_RS01390 (LFT51_01390) 285175..285411 + 237 WP_142383091.1 hypothetical protein -
LFT51_RS01395 (LFT51_01395) 286071..286265 - 195 WP_225342058.1 hypothetical protein -
LFT51_RS01400 (LFT51_01400) 286357..287361 - 1005 WP_042910419.1 tyrosine-type recombinase/integrase -
LFT51_RS01405 (LFT51_01405) 287538..288098 - 561 WP_042910420.1 RES domain-containing protein Toxin
LFT51_RS01410 (LFT51_01410) 288095..288436 - 342 WP_042910421.1 DUF2384 domain-containing protein Antitoxin
LFT51_RS01415 (LFT51_01415) 288484..289434 + 951 WP_226069250.1 hypothetical protein -
LFT51_RS01420 (LFT51_01420) 289431..289676 + 246 WP_226069251.1 hypothetical protein -
LFT51_RS01425 (LFT51_01425) 289854..290848 - 995 Protein_277 IS481 family transposase -
LFT51_RS01430 (LFT51_01430) 291417..291694 - 278 Protein_278 site-specific integrase -
LFT51_RS01435 (LFT51_01435) 291884..292516 - 633 WP_042910422.1 CAP domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 274624..415247 140623


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20501.00 Da        Isoelectric Point: 5.8540

>T218889 WP_042910420.1 NZ_CP084592:c288098-287538 [Mycobacterium intracellulare subsp. chimaera]
VSDALDEGLVQRIDACGTTPWSGTCYRYTTAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAKACMVEVERAANAASTT
AIKMLEAAYRLHHIQVEELNVLDLRTPESRDAVGLDDDDVYGDDWSACQAVGHTAWFLHMQGILVPAAGGIGLVISAYEQ
RTRPRQLHLRHSENLTPALYTQYRSS

Download         Length: 561 bp

>T218889 NZ_CP116117:40808-40960 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12612.51 Da        Isoelectric Point: 4.8483

>AT218889 WP_042910421.1 NZ_CP084592:c288436-288095 [Mycobacterium intracellulare subsp. chimaera]
MAMNALASTVSSAIERLGLTYEEVGDIVEASPRSVARWTSGQVVPQRLNKQRLIELAYVADALAEVLPRDQANMWMFSPN
RLLEHRKPADLIRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT218889 NZ_CP116117:c40758-40696 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I9ZD82

Antitoxin

Source ID Structure
AlphaFold DB A0A7I9ZDJ0

References