Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 63325..63866 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP084588 | ||
| Organism | Mycobacterium intracellulare subsp. chimaera strain 852 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | D5P595 |
| Locus tag | LFT50_RS30320 | Protein ID | WP_007172365.1 |
| Coordinates | 63325..63618 (-) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A854I1S2 |
| Locus tag | LFT50_RS30325 | Protein ID | WP_040624378.1 |
| Coordinates | 63615..63866 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LFT50_RS30290 (LFT50_30290) | 58655..59086 | - | 432 | WP_139315439.1 | hypothetical protein | - |
| LFT50_RS30295 (LFT50_30295) | 59317..59589 | - | 273 | WP_139315440.1 | hypothetical protein | - |
| LFT50_RS30300 (LFT50_30300) | 59713..60384 | - | 672 | WP_139315441.1 | hypothetical protein | - |
| LFT50_RS30305 (LFT50_30305) | 60494..61447 | - | 954 | WP_226057956.1 | DUF6036 family nucleotidyltransferase | - |
| LFT50_RS30310 (LFT50_30310) | 61688..62386 | - | 699 | WP_139315442.1 | hypothetical protein | - |
| LFT50_RS30315 (LFT50_30315) | 62400..63107 | - | 708 | WP_139315443.1 | hypothetical protein | - |
| LFT50_RS30320 (LFT50_30320) | 63325..63618 | - | 294 | WP_007172365.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LFT50_RS30325 (LFT50_30325) | 63615..63866 | - | 252 | WP_040624378.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| LFT50_RS30330 (LFT50_30330) | 63972..64478 | - | 507 | WP_007172367.1 | helix-turn-helix transcriptional regulator | - |
| LFT50_RS30335 (LFT50_30335) | 64785..65222 | + | 438 | WP_007172368.1 | WhiB family transcriptional regulator | - |
| LFT50_RS30340 (LFT50_30340) | 65278..65868 | + | 591 | WP_023363514.1 | hypothetical protein | - |
| LFT50_RS30345 (LFT50_30345) | 65831..66115 | + | 285 | WP_007172369.1 | hypothetical protein | - |
| LFT50_RS30350 (LFT50_30350) | 66492..68354 | + | 1863 | WP_023363516.1 | helicase associated domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | eccA5 / esxN | 1..95688 | 95688 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11261.74 Da Isoelectric Point: 6.9772
>T218887 WP_007172365.1 NZ_CP084588:c63618-63325 [Mycobacterium intracellulare subsp. chimaera]
VSAYVLSPAAQADLEQIWDYTHEHWGLDQAEQYLRELQRAIERAAANPRIGRACDEIRPGYRKLAAGSHMLFYRVTTQGF
LDVVRVLHQRMDVDRHL
VSAYVLSPAAQADLEQIWDYTHEHWGLDQAEQYLRELQRAIERAAANPRIGRACDEIRPGYRKLAAGSHMLFYRVTTQGF
LDVVRVLHQRMDVDRHL
Download Length: 294 bp
>T218887 NZ_CP116116:33429-33899 [Escherichia coli]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCTTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATTGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCTTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATTGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9203.22 Da Isoelectric Point: 5.8579
>AT218887 WP_040624378.1 NZ_CP084588:c63866-63615 [Mycobacterium intracellulare subsp. chimaera]
VGKNTSFSLDEHYSAFIEAEVAAGRYRSASDVVRSALRLLEDREIQLRALREALVAGERSGTSTPFDFDAFLDGKRAEKP
QGR
VGKNTSFSLDEHYSAFIEAEVAAGRYRSASDVVRSALRLLEDREIQLRALREALVAGERSGTSTPFDFDAFLDGKRAEKP
QGR
Download Length: 252 bp
>AT218887 NZ_CP116116:32989-33432 [Escherichia coli]
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACTTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACGGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACTTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACGGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1Y0TBP0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A854I1S2 |