Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
| Location | 50610..51292 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP084588 | ||
| Organism | Mycobacterium intracellulare subsp. chimaera strain 852 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A854IDQ2 |
| Locus tag | LFT50_RS30255 | Protein ID | WP_040624374.1 |
| Coordinates | 50876..51292 (+) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | D5P579 |
| Locus tag | LFT50_RS30250 | Protein ID | WP_007172349.1 |
| Coordinates | 50610..50873 (+) | Length | 88 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LFT50_RS30230 (LFT50_30230) | 45682..47217 | - | 1536 | WP_225336956.1 | type VII secretion protein EccB | - |
| LFT50_RS30235 (LFT50_30235) | 47241..48281 | - | 1041 | WP_023363502.1 | C40 family peptidase | - |
| LFT50_RS30240 (LFT50_30240) | 48367..49110 | - | 744 | WP_225336958.1 | hypothetical protein | - |
| LFT50_RS30245 (LFT50_30245) | 49534..50508 | - | 975 | WP_023363505.1 | hypothetical protein | - |
| LFT50_RS30250 (LFT50_30250) | 50610..50873 | + | 264 | WP_007172349.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| LFT50_RS30255 (LFT50_30255) | 50876..51292 | + | 417 | WP_040624374.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LFT50_RS30260 (LFT50_30260) | 51574..52905 | - | 1332 | WP_023363507.1 | IS256 family transposase | - |
| LFT50_RS30265 (LFT50_30265) | 53048..53629 | + | 582 | WP_007172352.1 | IS607 family transposase | - |
| LFT50_RS30270 (LFT50_30270) | 53629..55281 | + | 1653 | WP_040624340.1 | IS607 family element RNA-guided endonuclease TnpB | - |
| LFT50_RS30275 (LFT50_30275) | 55387..55525 | + | 139 | Protein_49 | type II toxin-antitoxin system VapC family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | eccA5 / esxN | 1..95688 | 95688 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 14879.84 Da Isoelectric Point: 5.4519
>T218886 WP_040624374.1 NZ_CP084588:50876-51292 [Mycobacterium intracellulare subsp. chimaera]
MIIDSSAIVALIQGEDPYTEQIAAAIAADPSPVMSTANAAECLIVLTNRHGATARTVFDRLRSEINLGFQPFTLEHAIAA
HRAYLHYGKGRHPAALNYGDTMAYATAKLAHEPLIAIGNDFTQTDLEFNGVIGYWPAP
MIIDSSAIVALIQGEDPYTEQIAAAIAADPSPVMSTANAAECLIVLTNRHGATARTVFDRLRSEINLGFQPFTLEHAIAA
HRAYLHYGKGRHPAALNYGDTMAYATAKLAHEPLIAIGNDFTQTDLEFNGVIGYWPAP
Download Length: 417 bp
>T218886 NZ_CP116115:4145295-4145759 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9884.20 Da Isoelectric Point: 4.8359
>AT218886 WP_007172349.1 NZ_CP084588:50610-50873 [Mycobacterium intracellulare subsp. chimaera]
MAFNVKDEEVIRFADELAARLHLPSRIDAIRYALRAQIEVTQSRTANRSAELLDVLKTEIWPLLDDRSPITKTEREQALG
YDTATGV
MAFNVKDEEVIRFADELAARLHLPSRIDAIRYALRAQIEVTQSRTANRSAELLDVLKTEIWPLLDDRSPITKTEREQALG
YDTATGV
Download Length: 264 bp
>AT218886 NZ_CP116115:4144960-4145295 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A854IDQ2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1Y0TBQ2 |