Detailed information of TA system TA218885

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 4437391..4437917
• Replicon: chromosome
• Accession: NZ_CP084586
• Organism: Mycobacterium intracellulare subsp. chimaera strain 852

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: S4ZDZ6
• Locus tag: LFT50_RS20455
• Protein ID: WP_008259048.1
• Coordinates: 4437615..4437917 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: S4ZFD0
• Locus tag: LFT50_RS20450
• Protein ID: WP_008259047.1
• Coordinates: 4437391..4437618 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LFT50_RS20425 (LFT50_20425)	4432462..4433574	-	1113	WP_226057885.1	MinD/ParA family protein	-
LFT50_RS20430 (LFT50_20430)	4433633..4434664	-	1032	WP_042912751.1	ATP-dependent 6-phosphofructokinase	-
LFT50_RS20435 (LFT50_20435)	4434708..4436201	-	1494	WP_042912754.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	-
LFT50_RS20440 (LFT50_20440)	4436198..4436497	-	300	WP_009952003.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
LFT50_RS20445 (LFT50_20445)	4436597..4437253	+	657	WP_087139897.1	amino acid-binding protein	-
LFT50_RS20450 (LFT50_20450)	4437391..4437618	+	228	WP_008259047.1	ribbon-helix-helix protein, CopG family	Antitoxin
LFT50_RS20455 (LFT50_20455)	4437615..4437917	+	303	WP_008259048.1	hypothetical protein	Toxin
LFT50_RS20460 (LFT50_20460)	4438033..4438341	-	309	WP_008259049.1	hypothetical protein	-
LFT50_RS20465 (LFT50_20465)	4438400..4441321	-	2922	WP_014712101.1	MMPL family transporter	-
LFT50_RS20470 (LFT50_20470)	4441318..4441722	-	405	WP_008259052.1	MmpS family transport accessory protein	-
LFT50_RS20475 (LFT50_20475)	4441969..4442487	+	519	WP_042912757.1	pyridoxamine 5'-phosphate oxidase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10473.31 Da
• Isoelectric Point: 4.5636

>T218885 WP_008259048.1 NZ_CP084586:4437615-4437917 [Mycobacterium intracellulare subsp. chimaera]
MIAPGDIAPRRDTRRDLYVAVLSNAIHLAANTGRVIVCPFIPGKIPDDTMAMVVPLTQPEGTLLPELVQWLPTSALGEPI
GAVSAAALSEAMSIVTALIT

Nucleotide

• Length: 303 bp

>T218885 NZ_CP116115:c4102413-4102099 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8173.14 Da
• Isoelectric Point: 6.4608

>AT218885 WP_008259047.1 NZ_CP084586:4437391-4437618 [Mycobacterium intracellulare subsp. chimaera]
MAKEKISVTVDAAVLADADSDAKAAGLNRSEMIERALRNEHLRRALHTYTTRTAPALNIDSYAGQVYEANRAADL

Nucleotide

• Length: 228 bp

>AT218885 NZ_CP116115:c4102102-4101686 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Structures

Toxin

• AlphaFold DB: S4ZDZ6

Antitoxin

• AlphaFold DB: S4ZFD0