Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-ParD |
| Location | 2798292..2799284 | Replicon | chromosome |
| Accession | NZ_CP084586 | ||
| Organism | Mycobacterium intracellulare subsp. chimaera strain 852 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | A0A854HPC2 |
| Locus tag | LFT50_RS13000 | Protein ID | WP_054585353.1 |
| Coordinates | 2798706..2799284 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | A0A854UQX7 |
| Locus tag | LFT50_RS12995 | Protein ID | WP_054585352.1 |
| Coordinates | 2798292..2798681 (+) | Length | 130 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LFT50_RS12975 (LFT50_12975) | 2793443..2794111 | - | 669 | WP_179300141.1 | hypothetical protein | - |
| LFT50_RS12980 (LFT50_12980) | 2794191..2795708 | + | 1518 | WP_054585349.1 | carboxylesterase/lipase family protein | - |
| LFT50_RS12985 (LFT50_12985) | 2795727..2797730 | + | 2004 | WP_054585350.1 | phosphotransferase | - |
| LFT50_RS12990 (LFT50_12990) | 2797727..2798221 | + | 495 | WP_054585351.1 | gluconokinase | - |
| LFT50_RS12995 (LFT50_12995) | 2798292..2798681 | + | 390 | WP_054585352.1 | hypothetical protein | Antitoxin |
| LFT50_RS13000 (LFT50_13000) | 2798706..2799284 | + | 579 | WP_054585353.1 | zeta toxin family protein | Toxin |
| LFT50_RS13005 (LFT50_13005) | 2799295..2800362 | - | 1068 | WP_054585354.1 | DoxX family protein | - |
| LFT50_RS13010 (LFT50_13010) | 2800458..2801018 | + | 561 | WP_008256422.1 | pyrazinamidase PncA | - |
| LFT50_RS13015 (LFT50_13015) | 2801018..2801818 | + | 801 | WP_054585355.1 | nuclear transport factor 2 family protein | - |
| LFT50_RS13020 (LFT50_13020) | 2801830..2802180 | - | 351 | WP_054585356.1 | DoxX family protein | - |
| LFT50_RS13025 (LFT50_13025) | 2802346..2803317 | + | 972 | WP_054585357.1 | sigma-70 family RNA polymerase sigma factor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21127.16 Da Isoelectric Point: 10.7751
>T218884 WP_054585353.1 NZ_CP084586:2798706-2799284 [Mycobacterium intracellulare subsp. chimaera]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPEESAGRAYDAAQIAADTRAKLIDLGRSFIAETVFSH
PSKLDLIRTAHRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNSRLRG
PRIVARLTGGMTIGSPDWPAWTPGTLRSRWAD
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPEESAGRAYDAAQIAADTRAKLIDLGRSFIAETVFSH
PSKLDLIRTAHRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNSRLRG
PRIVARLTGGMTIGSPDWPAWTPGTLRSRWAD
Download Length: 579 bp
>T218884 NZ_CP116115:c4037838-4037542 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
Antitoxin
Download Length: 130 a.a. Molecular weight: 13529.94 Da Isoelectric Point: 5.5559
>AT218884 WP_054585352.1 NZ_CP084586:2798292-2798681 [Mycobacterium intracellulare subsp. chimaera]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAAMAGQLATGELTVEEGVVFNAEI
SAAIEESLVHANYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAAMAGQLATGELTVEEGVVFNAEI
SAAIEESLVHANYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR
Download Length: 390 bp
>AT218884 NZ_CP116115:c4037540-4037145 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A854HPC2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A854UQX7 |