Detailed information of TA system TA218883

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 2467209..2467873
• Replicon: chromosome
• Accession: NZ_CP084586
• Organism: Mycobacterium intracellulare subsp. chimaera strain 852

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: J9WD27
• Locus tag: LFT50_RS11555
• Protein ID: WP_009954498.1
• Coordinates: 2467466..2467873 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LFT50_RS11550
• Protein ID: WP_009954496.1
• Coordinates: 2467209..2467469 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LFT50_RS11525 (LFT50_11525)	2463718..2464209	-	492	WP_014711439.1	DUF1707 domain-containing protein	-
LFT50_RS11530 (LFT50_11530)	2464279..2464875	+	597	WP_042911492.1	TetR/AcrR family transcriptional regulator	-
LFT50_RS11535 (LFT50_11535)	2464880..2466148	-	1269	WP_042911493.1	cytochrome P450	-
LFT50_RS11540 (LFT50_11540)	2466306..2466758	+	453	WP_042911495.1	VOC family protein	-
LFT50_RS11545 (LFT50_11545)	2466829..2467086	+	258	WP_042911496.1	hypothetical protein	-
LFT50_RS11550 (LFT50_11550)	2467209..2467469	+	261	WP_009954496.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LFT50_RS11555 (LFT50_11555)	2467466..2467873	+	408	WP_009954498.1	type II toxin-antitoxin system VapC family toxin	Toxin
LFT50_RS11560 (LFT50_11560)	2468051..2471152	+	3102	WP_042911498.1	DEAD/DEAH box helicase	-
LFT50_RS11565 (LFT50_11565)	2471214..2472779	-	1566	WP_042911499.1	serine/threonine-protein kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-125)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-66)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14293.28 Da
• Isoelectric Point: 4.2772

>T218883 WP_009954498.1 NZ_CP084586:2467466-2467873 [Mycobacterium intracellulare subsp. chimaera]
MSNPQVAGVLDTSVFIATESGRPLDAALIPDQVGTTVVTLAELHVGVLAASTSDIRAQRLATLESIADIEALPVDDDAAR
MWARLRIHLAETGQRVRINDLWIAAIAASRGLPVVTQDDDFAVLDGAANLTVIRV

Nucleotide

• Length: 408 bp

>T218883 NZ_CP116115:c3828235-3827828 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9526.85 Da
• Isoelectric Point: 9.1203

>AT218883 WP_009954496.1 NZ_CP084586:2467209-2467469 [Mycobacterium intracellulare subsp. chimaera]
MSEVASRELRNDTAGVLRRVRDGEDVTITVSGRPVAVLTAVVPQRRRWLSKTELLSRLPRVQADPGLREDLHALAGDTTE
ELGPIR

Nucleotide

• Length: 261 bp

>AT218883 NZ_CP116115:c3828482-3828216 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATTCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: J9WD27