Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VapB |
| Location | 1457151..1457713 | Replicon | chromosome |
| Accession | NZ_CP084586 | ||
| Organism | Mycobacterium intracellulare subsp. chimaera strain 852 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A081I0A5 |
| Locus tag | LFT50_RS07220 | Protein ID | WP_036454801.1 |
| Coordinates | 1457345..1457713 (+) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A081I0A4 |
| Locus tag | LFT50_RS07215 | Protein ID | WP_036455532.1 |
| Coordinates | 1457151..1457348 (+) | Length | 66 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LFT50_RS07180 (LFT50_07180) | 1452255..1453400 | - | 1146 | WP_179945068.1 | hypothetical protein | - |
| LFT50_RS07185 (LFT50_07185) | 1453530..1454603 | + | 1074 | WP_042910932.1 | redox-regulated ATPase YchF | - |
| LFT50_RS07190 (LFT50_07190) | 1454620..1455360 | + | 741 | WP_042910933.1 | aminoglycoside 3'-phosphotransferase | - |
| LFT50_RS07195 (LFT50_07195) | 1455448..1455732 | + | 285 | WP_020821851.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LFT50_RS07200 (LFT50_07200) | 1455747..1455992 | + | 246 | WP_042910934.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LFT50_RS07205 (LFT50_07205) | 1456028..1456579 | + | 552 | WP_036454798.1 | VOC family protein | - |
| LFT50_RS07210 (LFT50_07210) | 1456658..1457056 | + | 399 | WP_036454800.1 | VOC family protein | - |
| LFT50_RS07215 (LFT50_07215) | 1457151..1457348 | + | 198 | WP_036455532.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| LFT50_RS07220 (LFT50_07220) | 1457345..1457713 | + | 369 | WP_036454801.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LFT50_RS07225 (LFT50_07225) | 1457896..1458237 | + | 342 | WP_172417493.1 | hypothetical protein | - |
| LFT50_RS07230 (LFT50_07230) | 1458323..1458682 | + | 360 | WP_042910935.1 | hypothetical protein | - |
| LFT50_RS07235 (LFT50_07235) | 1458867..1459442 | + | 576 | WP_075630262.1 | C40 family peptidase | - |
| LFT50_RS07240 (LFT50_07240) | 1459805..1460128 | + | 324 | WP_036454806.1 | putative quinol monooxygenase | - |
| LFT50_RS07245 (LFT50_07245) | 1460166..1460999 | - | 834 | WP_036454808.1 | SAM-dependent methyltransferase | - |
| LFT50_RS07250 (LFT50_07250) | 1461034..1461717 | - | 684 | WP_036455537.1 | hypothetical protein | - |
| LFT50_RS07255 (LFT50_07255) | 1461864..1462073 | + | 210 | WP_072501223.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13435.74 Da Isoelectric Point: 6.4862
>T218881 WP_036454801.1 NZ_CP084586:1457345-1457713 [Mycobacterium intracellulare subsp. chimaera]
MILVDTAVWIDHLHTAELRLVKLLEIDQVGCHALVIEELALGSISRREVVLDLLANLRQFPTVQHAEILHLTGQRKLYGR
GLSAVDVHLMAAVALVEGAQLWTRDKRLKAASVDAGIALFDA
MILVDTAVWIDHLHTAELRLVKLLEIDQVGCHALVIEELALGSISRREVVLDLLANLRQFPTVQHAEILHLTGQRKLYGR
GLSAVDVHLMAAVALVEGAQLWTRDKRLKAASVDAGIALFDA
Download Length: 369 bp
>T218881 NZ_CP116115:c2862648-2862397 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Antitoxin
Download Length: 66 a.a. Molecular weight: 6871.88 Da Isoelectric Point: 11.6072
>AT218881 WP_036455532.1 NZ_CP084586:1457151-1457348 [Mycobacterium intracellulare subsp. chimaera]
MRTTVTIDDDLLAKAAELTGVRENVALLREGLQTLIRVESARRLAALGGTDAGAVAAPRRRRGTG
MRTTVTIDDDLLAKAAELTGVRENVALLREGLQTLIRVESARRLAALGGTDAGAVAAPRRRRGTG
Download Length: 198 bp
>AT218881 NZ_CP116115:c2862400-2862146 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A081I0A5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A081I0A4 |