Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-Phd |
| Location | 1455448..1455992 | Replicon | chromosome |
| Accession | NZ_CP084586 | ||
| Organism | Mycobacterium intracellulare subsp. chimaera strain 852 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A854HUL3 |
| Locus tag | LFT50_RS07200 | Protein ID | WP_042910934.1 |
| Coordinates | 1455747..1455992 (+) | Length | 82 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S4Z4W6 |
| Locus tag | LFT50_RS07195 | Protein ID | WP_020821851.1 |
| Coordinates | 1455448..1455732 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LFT50_RS07170 (LFT50_07170) | 1450522..1451121 | - | 600 | WP_009953444.1 | lipid droplet-associated protein | - |
| LFT50_RS07175 (LFT50_07175) | 1451211..1452209 | + | 999 | WP_042910931.1 | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | - |
| LFT50_RS07180 (LFT50_07180) | 1452255..1453400 | - | 1146 | WP_179945068.1 | hypothetical protein | - |
| LFT50_RS07185 (LFT50_07185) | 1453530..1454603 | + | 1074 | WP_042910932.1 | redox-regulated ATPase YchF | - |
| LFT50_RS07190 (LFT50_07190) | 1454620..1455360 | + | 741 | WP_042910933.1 | aminoglycoside 3'-phosphotransferase | - |
| LFT50_RS07195 (LFT50_07195) | 1455448..1455732 | + | 285 | WP_020821851.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LFT50_RS07200 (LFT50_07200) | 1455747..1455992 | + | 246 | WP_042910934.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LFT50_RS07205 (LFT50_07205) | 1456028..1456579 | + | 552 | WP_036454798.1 | VOC family protein | - |
| LFT50_RS07210 (LFT50_07210) | 1456658..1457056 | + | 399 | WP_036454800.1 | VOC family protein | - |
| LFT50_RS07215 (LFT50_07215) | 1457151..1457348 | + | 198 | WP_036455532.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| LFT50_RS07220 (LFT50_07220) | 1457345..1457713 | + | 369 | WP_036454801.1 | type II toxin-antitoxin system VapC family toxin | - |
| LFT50_RS07225 (LFT50_07225) | 1457896..1458237 | + | 342 | WP_172417493.1 | hypothetical protein | - |
| LFT50_RS07230 (LFT50_07230) | 1458323..1458682 | + | 360 | WP_042910935.1 | hypothetical protein | - |
| LFT50_RS07235 (LFT50_07235) | 1458867..1459442 | + | 576 | WP_075630262.1 | C40 family peptidase | - |
| LFT50_RS07240 (LFT50_07240) | 1459805..1460128 | + | 324 | WP_036454806.1 | putative quinol monooxygenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9380.95 Da Isoelectric Point: 11.2612
>T218880 WP_042910934.1 NZ_CP084586:1455747-1455992 [Mycobacterium intracellulare subsp. chimaera]
MTAAAKRALTHLLPESVAIACWEFIRGPLAENPQRVGKPLRGQLEGRYSARRGEFRVIYRIFDERVVVPVIHIAHRRDVY
R
MTAAAKRALTHLLPESVAIACWEFIRGPLAENPQRVGKPLRGQLEGRYSARRGEFRVIYRIFDERVVVPVIHIAHRRDVY
R
Download Length: 246 bp
>T218880 NZ_CP084586:1455747-1455992 [Mycobacterium intracellulare subsp. chimaera]
ATGACGGCAGCTGCGAAGAGGGCGCTCACTCATTTGTTGCCCGAGTCGGTGGCCATTGCTTGCTGGGAGTTCATTCGGGG
TCCGCTCGCGGAGAACCCGCAGCGGGTGGGCAAGCCGCTTCGCGGCCAGTTGGAAGGGCGATACTCGGCGCGCAGGGGCG
AGTTTCGCGTCATTTACCGGATCTTCGACGAACGGGTGGTGGTCCCCGTCATCCACATCGCGCATCGCCGCGACGTTTAC
CGGTGA
ATGACGGCAGCTGCGAAGAGGGCGCTCACTCATTTGTTGCCCGAGTCGGTGGCCATTGCTTGCTGGGAGTTCATTCGGGG
TCCGCTCGCGGAGAACCCGCAGCGGGTGGGCAAGCCGCTTCGCGGCCAGTTGGAAGGGCGATACTCGGCGCGCAGGGGCG
AGTTTCGCGTCATTTACCGGATCTTCGACGAACGGGTGGTGGTCCCCGTCATCCACATCGCGCATCGCCGCGACGTTTAC
CGGTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10513.88 Da Isoelectric Point: 4.3705
>AT218880 WP_020821851.1 NZ_CP084586:1455448-1455732 [Mycobacterium intracellulare subsp. chimaera]
MSTLPLAEVRANLSKLVDEAVRTHERIEVTRQGRRAAVILSADDFDSIMETLAILSDQDLMREVRAAESEAEDGALYTLD
QVTEEMRAVGRLPR
MSTLPLAEVRANLSKLVDEAVRTHERIEVTRQGRRAAVILSADDFDSIMETLAILSDQDLMREVRAAESEAEDGALYTLD
QVTEEMRAVGRLPR
Download Length: 285 bp
>AT218880 NZ_CP084586:1455448-1455732 [Mycobacterium intracellulare subsp. chimaera]
ATGTCGACGCTTCCGCTGGCCGAGGTCCGAGCCAACCTTTCCAAGCTGGTCGACGAGGCCGTCCGGACCCATGAGCGCAT
CGAGGTCACCAGGCAAGGTCGCCGCGCGGCGGTGATTCTCAGCGCGGATGACTTCGATTCGATTATGGAAACTCTGGCCA
TCCTCAGCGATCAAGACTTGATGCGCGAAGTCCGAGCGGCAGAGTCAGAGGCAGAGGACGGCGCGCTCTACACACTCGAT
CAGGTGACCGAGGAGATGCGTGCTGTCGGCCGGCTCCCGCGGTGA
ATGTCGACGCTTCCGCTGGCCGAGGTCCGAGCCAACCTTTCCAAGCTGGTCGACGAGGCCGTCCGGACCCATGAGCGCAT
CGAGGTCACCAGGCAAGGTCGCCGCGCGGCGGTGATTCTCAGCGCGGATGACTTCGATTCGATTATGGAAACTCTGGCCA
TCCTCAGCGATCAAGACTTGATGCGCGAAGTCCGAGCGGCAGAGTCAGAGGCAGAGGACGGCGCGCTCTACACACTCGAT
CAGGTGACCGAGGAGATGCGTGCTGTCGGCCGGCTCCCGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A854HUL3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S4Z4W6 |