218879

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1213497..1214150 Replicon chromosome
Accession NZ_CP084586
Organism Mycobacterium intracellulare subsp. chimaera strain 852

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag LFT50_RS06065 Protein ID WP_008253911.1
Coordinates 1213689..1214150 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID X8A187
Locus tag LFT50_RS06060 Protein ID WP_009957321.1
Coordinates 1213497..1213685 (+) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFT50_RS06050 (LFT50_06050) 1209470..1211047 + 1578 WP_042911067.1 serine hydrolase -
LFT50_RS06055 (LFT50_06055) 1211044..1213431 + 2388 WP_042910814.1 cation-translocating P-type ATPase -
LFT50_RS06060 (LFT50_06060) 1213497..1213685 + 189 WP_009957321.1 antitoxin Antitoxin
LFT50_RS06065 (LFT50_06065) 1213689..1214150 + 462 WP_008253911.1 SRPBCC family protein Toxin
LFT50_RS06070 (LFT50_06070) 1214237..1215007 + 771 WP_042910815.1 VOC family protein -
LFT50_RS06075 (LFT50_06075) 1215081..1215515 + 435 WP_008253914.1 hypothetical protein -
LFT50_RS06080 (LFT50_06080) 1215520..1216008 - 489 WP_036454690.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
LFT50_RS06085 (LFT50_06085) 1216008..1217522 - 1515 WP_042910816.1 carotenoid oxygenase family protein -
LFT50_RS06090 (LFT50_06090) 1217525..1218745 - 1221 WP_042910817.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 16639.20 Da        Isoelectric Point: 8.5617

>T218879 WP_008253911.1 NZ_CP084586:1213689-1214150 [Mycobacterium intracellulare subsp. chimaera]
MAKLSGSIDVPLPPEVAWQHASDLSRYKDWLTIHRVWRSALPDEIEKGSVVESIVEVKGMPNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKIQPKGDGSLVSFDVHLGGPALFGPIGMIVAAALRGDIDQSLENFVTVFTRPDPSSNGHR

Download         Length: 462 bp

>T218879 NZ_CP116115:c2629127-2629025 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6698.30 Da        Isoelectric Point: 4.4702

>AT218879 WP_009957321.1 NZ_CP084586:1213497-1213685 [Mycobacterium intracellulare subsp. chimaera]
MGFLDKAKDLLSQNADKVETAIDKAGEFVDEKTQGKYSDTIHQVQEQAKKAAGAADTGDQQN

Download         Length: 189 bp

>AT218879 NZ_CP116115:2628987-2629255 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB X8A187

References