Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PHD(antitoxin) |
| Location | 992185..992868 | Replicon | chromosome |
| Accession | NZ_CP084586 | ||
| Organism | Mycobacterium intracellulare subsp. chimaera strain 852 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | D5PEA4 |
| Locus tag | LFT50_RS04925 | Protein ID | WP_007168487.1 |
| Coordinates | 992185..992592 (-) | Length | 136 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A1X1XBB9 |
| Locus tag | LFT50_RS04930 | Protein ID | WP_033711258.1 |
| Coordinates | 992596..992868 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LFT50_RS04890 (LFT50_04890) | 987409..987808 | + | 400 | Protein_963 | replicative DNA helicase | - |
| LFT50_RS04895 (LFT50_04895) | 987832..988080 | + | 249 | Protein_964 | transposase | - |
| LFT50_RS04900 (LFT50_04900) | 988237..989421 | + | 1185 | WP_040624521.1 | IS30 family transposase | - |
| LFT50_RS30940 | 989523..989618 | - | 96 | WP_230484118.1 | hypothetical protein | - |
| LFT50_RS04910 (LFT50_04910) | 989751..989843 | - | 93 | Protein_967 | ATPase | - |
| LFT50_RS30945 | 989887..990009 | + | 123 | WP_255250777.1 | hypothetical protein | - |
| LFT50_RS04915 (LFT50_04915) | 991457..991762 | - | 306 | WP_007168485.1 | hypothetical protein | - |
| LFT50_RS04920 (LFT50_04920) | 991823..992164 | - | 342 | WP_007168486.1 | hypothetical protein | - |
| LFT50_RS04925 (LFT50_04925) | 992185..992592 | - | 408 | WP_007168487.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LFT50_RS04930 (LFT50_04930) | 992596..992868 | - | 273 | WP_033711258.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| LFT50_RS04935 (LFT50_04935) | 993364..994599 | - | 1236 | WP_042909886.1 | IS256 family transposase | - |
| LFT50_RS04940 (LFT50_04940) | 995241..995426 | + | 186 | WP_132160383.1 | hypothetical protein | - |
| LFT50_RS04945 (LFT50_04945) | 995500..995916 | - | 417 | WP_007168492.1 | type II toxin-antitoxin system VapC family toxin | - |
| LFT50_RS04950 (LFT50_04950) | 995913..996164 | - | 252 | WP_007168493.1 | ribbon-helix-helix protein, CopG family | - |
| LFT50_RS04955 (LFT50_04955) | 996966..997361 | + | 396 | WP_007168495.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 971543..1014177 | 42634 | |
| - | flank | IS/Tn | - | - | 993364..994599 | 1235 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 14464.55 Da Isoelectric Point: 4.6697
>T218878 WP_007168487.1 NZ_CP084586:c992592-992185 [Mycobacterium intracellulare subsp. chimaera]
VIYLDTSALVKLIRIEVESDALADWLDERTETRWITSALAEVELPRAIRAVAPNGLSAVPSVLARLDRFEIDQVIRATAA
AYPDPALRSLDAIHLATAQIAASTAPLTAMVAYDSRLSDAARALGITIVTPGRNS
VIYLDTSALVKLIRIEVESDALADWLDERTETRWITSALAEVELPRAIRAVAPNGLSAVPSVLARLDRFEIDQVIRATAA
AYPDPALRSLDAIHLATAQIAASTAPLTAMVAYDSRLSDAARALGITIVTPGRNS
Download Length: 408 bp
>T218878 NZ_CP116115:c2290259-2289981 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 9764.35 Da Isoelectric Point: 8.7382
>AT218878 WP_033711258.1 NZ_CP084586:c992868-992596 [Mycobacterium intracellulare subsp. chimaera]
MSEVPLRMLNQETAKVLARVKRGEEITLTERGEVIARIIPATAGPLDALITAGRVQPATLAGPAPRPTVPMHDNLDAGAL
LQRLRAEERY
MSEVPLRMLNQETAKVLARVKRGEEITLTERGEVIARIIPATAGPLDALITAGRVQPATLAGPAPRPTVPMHDNLDAGAL
LQRLRAEERY
Download Length: 273 bp
>AT218878 NZ_CP116115:c2289981-2289697 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1X1XAJ9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1X1XBB9 |