218877

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 927231..927898 Replicon chromosome
Accession NZ_CP084586
Organism Mycobacterium intracellulare subsp. chimaera strain 852

Toxin (Protein)


Gene name vapC Uniprot ID D5PE24
Locus tag LFT50_RS04580 Protein ID WP_007168407.1
Coordinates 927506..927898 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5PE23
Locus tag LFT50_RS04575 Protein ID WP_007168406.1
Coordinates 927231..927506 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFT50_RS04545 (LFT50_04545) 923051..923284 - 234 Protein_894 transposase -
LFT50_RS04550 (LFT50_04550) 923353..924465 - 1113 Protein_895 ISL3 family transposase -
LFT50_RS04555 (LFT50_04555) 924637..925281 - 645 WP_019731991.1 DDE-type integrase/transposase/recombinase -
LFT50_RS04565 (LFT50_04565) 925420..926123 - 704 Protein_897 phosphoglycerate mutase family protein -
LFT50_RS04570 (LFT50_04570) 926206..927078 + 873 WP_007168405.1 MaoC/PaaZ C-terminal domain-containing protein -
LFT50_RS04575 (LFT50_04575) 927231..927506 + 276 WP_007168406.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LFT50_RS04580 (LFT50_04580) 927506..927898 + 393 WP_007168407.1 type II toxin-antitoxin system VapC family toxin Toxin
LFT50_RS04585 (LFT50_04585) 928046..929205 - 1160 Protein_901 trehalose-phosphatase -
LFT50_RS04590 (LFT50_04590) 929247..930585 - 1339 Protein_902 WS/DGAT domain-containing protein -
LFT50_RS04595 (LFT50_04595) 930745..930969 - 225 Protein_903 IS1595 family transposase -
LFT50_RS04600 (LFT50_04600) 931230..932639 + 1410 Protein_904 IS1182 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-45)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14305.73 Da        Isoelectric Point: 10.5032

>T218877 WP_007168407.1 NZ_CP084586:927506-927898 [Mycobacterium intracellulare subsp. chimaera]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRLPRVSSALARTEVMRALLHKGESARRAGRRALASLDLLRIDNRLLDLAG
GLLPIELRTLDAIHLATAQRLGMDLGRLCTYDDRMRDAAEALGMAVIAPS

Download         Length: 393 bp

>T218877 NZ_CP116115:c2003851-2003744 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10150.63 Da        Isoelectric Point: 5.1881

>AT218877 WP_007168406.1 NZ_CP084586:927231-927506 [Mycobacterium intracellulare subsp. chimaera]
MSTVGVRELRQRASELLRRVEAGETIEITDRGRPIALLSPMPEGGPYQQMLASGGIERATLDFDDLPEPVRLKTGIELPS
VTLARLREHER

Download         Length: 276 bp

>AT218877 NZ_CP116115:2003904-2003965 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XV84

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XUZ3

References