218876

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 717110..717639 Replicon chromosome
Accession NZ_CP084586
Organism Mycobacterium intracellulare subsp. chimaera strain 852

Toxin (Protein)


Gene name Rv0299 Uniprot ID X7VD93
Locus tag LFT50_RS03635 Protein ID WP_007172144.1
Coordinates 717110..717415 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID A0A1X1WNE2
Locus tag LFT50_RS03640 Protein ID WP_042910679.1
Coordinates 717412..717639 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFT50_RS03605 (LFT50_03605) 712188..712328 + 141 WP_007172137.1 hypothetical protein -
LFT50_RS03610 (LFT50_03610) 712325..712711 + 387 WP_007172138.1 YbaB/EbfC family nucleoid-associated protein -
LFT50_RS03615 (LFT50_03615) 712781..713458 + 678 WP_101930854.1 hypothetical protein -
LFT50_RS03620 (LFT50_03620) 713458..713790 + 333 WP_033717256.1 hypothetical protein -
LFT50_RS03625 (LFT50_03625) 714078..714365 + 288 WP_007172141.1 hypothetical protein -
LFT50_RS03630 (LFT50_03630) 714384..716738 + 2355 WP_007172142.1 hypothetical protein -
LFT50_RS03635 (LFT50_03635) 717110..717415 - 306 WP_007172144.1 hypothetical protein Toxin
LFT50_RS03640 (LFT50_03640) 717412..717639 - 228 WP_042910679.1 ribbon-helix-helix protein, CopG family Antitoxin
LFT50_RS03645 (LFT50_03645) 717775..717947 + 173 Protein_711 type II toxin-antitoxin system prevent-host-death family antitoxin -
LFT50_RS03650 (LFT50_03650) 718125..719615 + 1491 WP_007172147.1 type VII secretion protein EccB -
LFT50_RS03655 (LFT50_03655) 719689..720744 + 1056 WP_007172148.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 10428.23 Da        Isoelectric Point: 3.9382

>T218876 WP_007172144.1 NZ_CP084586:c717415-717110 [Mycobacterium intracellulare subsp. chimaera]
VITPGDITPGRDTNQELYVVVLSNTIHLAAATGQVIICPFIPGEIPSSTMAMIVTVLQPKGVVLPELIQWLPVAALDQPI
GNIGGIALADTTTTAVTALIS

Download         Length: 306 bp

>T218876 NZ_CP116115:1247394-1247696 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8167.24 Da        Isoelectric Point: 5.0079

>AT218876 WP_042910679.1 NZ_CP084586:c717639-717412 [Mycobacterium intracellulare subsp. chimaera]
MAKAKVSVMIEEAVLAAADADAQAAGLNRSEMIERALHNEHLRISLENYTTHTVPTLDIDAYAEKIYQANRAAGL

Download         Length: 228 bp

>AT218876 NZ_CP116115:1247732-1248073 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XDZ0

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1WNE2

References