Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2297305..2297833 Replicon chromosome
Accession NZ_CP084578
Organism Sulfurimonas sp. SWIR-19

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LCX93_RS11950 Protein ID WP_226066480.1
Coordinates 2297305..2297589 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LCX93_RS11955 Protein ID WP_226066481.1
Coordinates 2297576..2297833 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCX93_RS11925 (LCX93_11925) 2294004..2294522 - 519 WP_226066475.1 ferritin-like domain-containing protein -
LCX93_RS11930 (LCX93_11930) 2294590..2295705 - 1116 WP_226066476.1 HAMP domain-containing sensor histidine kinase -
LCX93_RS11935 (LCX93_11935) 2295698..2296345 - 648 WP_226066477.1 response regulator transcription factor -
LCX93_RS11940 (LCX93_11940) 2296501..2296797 + 297 WP_226066478.1 hypothetical protein -
LCX93_RS11945 (LCX93_11945) 2296986..2297219 + 234 WP_226066479.1 helix-turn-helix transcriptional regulator -
LCX93_RS11950 (LCX93_11950) 2297305..2297589 - 285 WP_226066480.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LCX93_RS11955 (LCX93_11955) 2297576..2297833 - 258 WP_226066481.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LCX93_RS11960 (LCX93_11960) 2297881..2298363 - 483 WP_226066482.1 hypothetical protein -
LCX93_RS11965 (LCX93_11965) 2298374..2299660 - 1287 WP_226066483.1 Glu/Leu/Phe/Val dehydrogenase -
LCX93_RS11970 (LCX93_11970) 2299674..2301131 - 1458 WP_226066484.1 mercury(II) reductase -
LCX93_RS11975 (LCX93_11975) 2301345..2301692 - 348 WP_226066485.1 metalloregulator ArsR/SmtB family transcription factor -
LCX93_RS11980 (LCX93_11980) 2301817..2302203 + 387 WP_226066486.1 FixH family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II bacterial toxin-antitoxin system, ParE-like toxin

(8-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-61)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11279.32 Da        Isoelectric Point: 10.6309

>T218873 WP_226066480.1 NZ_CP084578:c2297589-2297305 [Sulfurimonas sp. SWIR-19]
MSLYRLQFTKNAKKEWDKLDHSIQLQLHKKLKQRLQNPKVPSAKLSGFDNVYKIKLRNSGYRLAYEVKDVEIIVIVLKIG
KRENFYELLRDFLK

Download         Length: 285 bp

>T218873 NZ_CP116115:729616-729930 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9714.02 Da        Isoelectric Point: 4.2065

>AT218873 WP_226066481.1 NZ_CP084578:c2297833-2297576 [Sulfurimonas sp. SWIR-19]
MKQILANYTASITELKKSPTKLLDEAGNEPIAILNHNTPSAYLVPSSYYEKIMDILDEHYLEKEVKEALNYSKDELVEVD
IDELI

Download         Length: 258 bp

>AT218873 NZ_CP116115:729380-729613 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References