Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1388352..1388839 Replicon chromosome
Accession NZ_CP084561
Organism Arthrobacter sp. FW305-BF8

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LFT45_RS06195 Protein ID WP_236809045.1
Coordinates 1388537..1388839 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LFT45_RS06190 Protein ID WP_236809042.1
Coordinates 1388352..1388516 (+) Length 55 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFT45_RS06170 (LFT45_06200) 1383610..1384578 + 969 WP_236807509.1 sugar ABC transporter permease -
LFT45_RS06175 (LFT45_06205) 1384575..1385510 + 936 WP_236807514.1 carbohydrate ABC transporter permease -
LFT45_RS06180 (LFT45_06210) 1385566..1386645 + 1080 WP_272912773.1 NAD(P)-dependent alcohol dehydrogenase -
LFT45_RS06185 (LFT45_06215) 1386671..1388137 + 1467 WP_236807516.1 mannitol dehydrogenase family protein -
LFT45_RS06190 (LFT45_06220) 1388352..1388516 + 165 WP_236809042.1 DUF3018 family protein Antitoxin
LFT45_RS06195 (LFT45_06225) 1388537..1388839 + 303 WP_236809045.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LFT45_RS06200 (LFT45_06230) 1388868..1389653 - 786 WP_236807518.1 DUF2220 domain-containing protein -
LFT45_RS06205 (LFT45_06235) 1389753..1391000 + 1248 WP_236809048.1 IS256 family transposase -
LFT45_RS06210 (LFT45_06240) 1390956..1391540 - 585 WP_236807519.1 DUF3322 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-95)

Antitoxin

Antitoxin MazE-like

(1-52)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10784.52 Da        Isoelectric Point: 10.0824

>T218870 WP_236809045.1 NZ_CP084561:1388537-1388839 [Arthrobacter sp. FW305-BF8]
VSGGTYAQKPRPALIIQDDLFAASESVTLLPLTSHLTDAPLLRLTVEPGQLTGLERVSQIMVDKLTTVRRSNLGQRVGRI
DSKTMVAVEQSLAVFLGLGR

Download         Length: 303 bp

>T218870 NZ_CP116115:c576221-575964 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 55 a.a.        Molecular weight: 6502.07 Da        Isoelectric Point: 4.1546

>AT218870 WP_236809042.1 NZ_CP084561:1388352-1388516 [Arthrobacter sp. FW305-BF8]
MRERGFRQIQLWVPDTRTEKFRYEAERQALAVADSDRAGDDQDFIEQISEDWPE

Download         Length: 165 bp

>AT218870 NZ_CP116115:c575952-575407 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCGGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References