Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-ArgA
Location 4879658..4880477 Replicon chromosome
Accession NZ_CP084542
Organism Klebsiella michiganensis strain YL9

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag LD277_RS23380 Protein ID WP_004110819.1
Coordinates 4880220..4880477 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag LD277_RS23375 Protein ID WP_014837489.1
Coordinates 4879658..4880209 (-) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LD277_RS23345 (LD277_23365) 4875582..4876355 + 774 WP_088168442.1 Zygote formation protein zyg1 -
LD277_RS23350 (LD277_23370) 4876666..4877139 + 474 WP_032693194.1 hypothetical protein -
LD277_RS23355 (LD277_23375) 4877408..4877757 - 350 Protein_4599 type II toxin-antitoxin system VapC family toxin -
LD277_RS23360 (LD277_23380) 4877820..4877978 - 159 Protein_4600 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
LD277_RS23365 (LD277_23385) 4878012..4878758 - 747 WP_223226754.1 class I SAM-dependent methyltransferase -
LD277_RS23370 (LD277_23390) 4879182..4879544 - 363 Protein_4602 class I SAM-dependent methyltransferase -
LD277_RS23375 (LD277_23395) 4879658..4880209 - 552 WP_014837489.1 N-acetyltransferase Antitoxin
LD277_RS23380 (LD277_23400) 4880220..4880477 - 258 WP_004110819.1 YjhX family toxin Toxin
LD277_RS23385 (LD277_23405) 4881153..4882337 + 1185 WP_014228054.1 mannonate dehydratase -
LD277_RS23390 (LD277_23410) 4882411..4883886 + 1476 WP_014228053.1 fructuronate reductase -
LD277_RS23395 (LD277_23415) 4884025..4884801 + 777 WP_004847986.1 Uxu operon transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(22-130)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T218863 WP_004110819.1 NZ_CP084542:c4880477-4880220 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

>T218863 NZ_CP116111:c79161-79012 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 19902.64 Da        Isoelectric Point: 6.4913

>AT218863 WP_014837489.1 NZ_CP084542:c4880209-4879658 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGELIRHGIEQLKAMGSQAVFVLGHAAYYPRHGFEPGAGDKGYPAPYPIPAAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Download         Length: 552 bp

>AT218863 NZ_CP116111:79205-79266 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure

References