Detailed information of TA system TA218850

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 4611217..4611742
• Replicon: chromosome
• Accession: NZ_CP084541
• Organism: Streptomyces marincola strain SCSIO 64649

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LC193_RS20350
• Protein ID: WP_226076233.1
• Coordinates: 4611217..4611480 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LC193_RS20355
• Protein ID: WP_226076234.1
• Coordinates: 4611473..4611742 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LC193_RS20325 (LC193_20325)	4606676..4607023	-	348	WP_226076221.1	exodeoxyribonuclease VII small subunit	-
LC193_RS20330 (LC193_20330)	4607020..4608255	-	1236	WP_226076224.1	exodeoxyribonuclease VII large subunit	-
LC193_RS20335 (LC193_20335)	4608317..4609300	+	984	WP_226076227.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
LC193_RS20340 (LC193_20340)	4609340..4609678	-	339	WP_159029774.1	hypothetical protein	-
LC193_RS20345 (LC193_20345)	4609999..4611087	+	1089	WP_226076230.1	redox-regulated ATPase YchF	-
LC193_RS20350 (LC193_20350)	4611217..4611480	-	264	WP_226076233.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LC193_RS20355 (LC193_20355)	4611473..4611742	-	270	WP_226076234.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LC193_RS20360 (LC193_20360)	4611767..4611961	+	195	Protein_4007	type II toxin-antitoxin system prevent-host-death family antitoxin	-
LC193_RS20365 (LC193_20365)	4612049..4612351	+	303	WP_226078799.1	Txe/YoeB family addiction module toxin	-
LC193_RS20370 (LC193_20370)	4612374..4613315	+	942	WP_226076236.1	MerR family transcriptional regulator	-
LC193_RS20375 (LC193_20375)	4613600..4614784	+	1185	WP_226076238.1	acyl-CoA dehydrogenase	-
LC193_RS20380 (LC193_20380)	4614826..4616274	-	1449	WP_226076239.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-56)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10084.54 Da
• Isoelectric Point: 8.5042

>T218850 WP_226076233.1 NZ_CP084541:c4611480-4611217 [Streptomyces marincola]
VSEYRTVFRPEAQAELRKIPRDMALRILAKLTELETDPLGFNTTALVSQPERRRLRVGDYRVVYTIDNGELVVWVVHVGH
RSTVYDT

Nucleotide

• Length: 264 bp

>T218850 NZ_CP116110:1799743-1799994 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10259.67 Da
• Isoelectric Point: 4.6265

>AT218850 WP_226076234.1 NZ_CP084541:c4611742-4611473 [Streptomyces marincola]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIEVLRRYQEWEEREINRIIDERMANPAPGVPIEDV
MRETLARGE

Nucleotide

• Length: 270 bp

>AT218850 NZ_CP116110:1799991-1800245 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA