Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3239482..3240116 Replicon chromosome
Accession NZ_CP084541
Organism Streptomyces marincola strain SCSIO 64649

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LC193_RS13870 Protein ID WP_226074399.1
Coordinates 3239694..3240116 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LC193_RS13865 Protein ID WP_226074398.1
Coordinates 3239482..3239697 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LC193_RS13860 (LC193_13860) 3237937..3238923 + 987 WP_226074396.1 hypothetical protein -
LC193_RS13865 (LC193_13865) 3239482..3239697 + 216 WP_226074398.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LC193_RS13870 (LC193_13870) 3239694..3240116 + 423 WP_226074399.1 PIN domain nuclease Toxin
LC193_RS13875 (LC193_13875) 3240398..3240547 - 150 Protein_2732 aminotransferase -
LC193_RS13880 (LC193_13880) 3240694..3240915 + 222 WP_226074400.1 hypothetical protein -
LC193_RS13885 (LC193_13885) 3241028..3242152 - 1125 WP_226074401.1 serine hydrolase domain-containing protein -
LC193_RS13890 (LC193_13890) 3242304..3242708 - 405 WP_226074402.1 DUF5997 family protein -
LC193_RS13895 (LC193_13895) 3242768..3243532 + 765 WP_226074403.1 LysR family substrate-binding domain-containing protein -
LC193_RS13900 (LC193_13900) 3243930..3244613 + 684 WP_226074405.1 glycoside hydrolase family 11 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-49)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15379.25 Da        Isoelectric Point: 4.8835

>T218849 WP_226074399.1 NZ_CP084541:3239694-3240116 [Streptomyces marincola]
VNAAQFLIDTSALARFLRGDAEQHGWDQAAAAGLIATCPITELEFFYSARSAEDRAQGIEDMRMIFSWVPVDDRAYTRAW
QVQEALTRRGQHRSAGAVDLVVAATAELQGLTLLHRDRDFDCVAAVTGQALQWYGPAPGK

Download         Length: 423 bp

>T218849 NZ_CP116110:958710-959045 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTCG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7980.01 Da        Isoelectric Point: 5.1213

>AT218849 WP_226074398.1 NZ_CP084541:3239482-3239697 [Streptomyces marincola]
MSRTVIDLDDELVADVAKALGTSTKKETVNTALREVLENRRRALALTRLRAAADEGAFDLDLFEDKANYRR

Download         Length: 216 bp

>AT218849 NZ_CP116110:958462-958710 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGACTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References