Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 307505..308144 Replicon chromosome
Accession NZ_CP084539
Organism Peribacillus frigoritolerans strain Ant232

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag LDO17_RS01540 Protein ID WP_034306610.1
Coordinates 307794..308144 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag LDO17_RS01535 Protein ID WP_034306380.1
Coordinates 307505..307786 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO17_RS01515 303643..304233 - 591 WP_048682037.1 rhomboid family intramembrane serine protease -
LDO17_RS01520 304342..304692 + 351 WP_048682039.1 holo-ACP synthase -
LDO17_RS01525 304935..305939 + 1005 WP_048682041.1 outer membrane lipoprotein carrier protein LolA -
LDO17_RS01530 306157..307344 + 1188 WP_048682044.1 alanine racemase -
LDO17_RS01535 307505..307786 + 282 WP_034306380.1 antitoxin EndoAI Antitoxin
LDO17_RS01540 307794..308144 + 351 WP_034306610.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LDO17_RS01545 308558..309385 + 828 WP_048682050.1 RsbT co-antagonist protein RsbRA -
LDO17_RS01550 309388..309744 + 357 WP_048682053.1 STAS domain-containing protein -
LDO17_RS01555 309748..310149 + 402 WP_048682056.1 anti-sigma regulatory factor -
LDO17_RS01560 310159..311169 + 1011 WP_048682059.1 PP2C family protein-serine/threonine phosphatase -
LDO17_RS01565 311229..311561 + 333 WP_034306369.1 anti-sigma factor antagonist -
LDO17_RS01570 311558..312031 + 474 WP_034306366.1 anti-sigma B factor RsbW -
LDO17_RS01575 312009..312797 + 789 WP_034306363.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12955.06 Da        Isoelectric Point: 7.2029

>T218848 WP_034306610.1 NZ_CP084539:307794-308144 [Peribacillus frigoritolerans]
IVVKRGDVYFADLSPVVGSEQGGTRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEPMMQKVNEALQISLGLIEF

Download         Length: 351 bp

>T218848 NZ_CP116110:821254-821661 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10713.13 Da        Isoelectric Point: 5.9054

>AT218848 WP_034306380.1 NZ_CP084539:307505-307786 [Peribacillus frigoritolerans]
VSESSATREILIRLPQNFLTELDGYASEENVNRSEFIYRATKMYLRERKKKEFRESMKRGYIEMAAINLTIASEAFQAEF
EAGHCVERLVSGG

Download         Length: 282 bp

>AT218848 NZ_CP116110:821007-821273 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References