Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 45073..45598 | Replicon | plasmid pSE211 |
| Accession | NZ_CP084533 | ||
| Organism | Salmonella enterica subsp. enterica serovar Enteritidis strain SE211 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | I3W3D5 |
| Locus tag | LDP70_RS23020 | Protein ID | WP_001159863.1 |
| Coordinates | 45073..45378 (-) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7S5D0 |
| Locus tag | LDP70_RS23025 | Protein ID | WP_000813641.1 |
| Coordinates | 45380..45598 (-) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LDP70_RS22980 (LDP70_22980) | 40452..40997 | - | 546 | WP_071591236.1 | inverse autotransporter beta domain-containing protein | - |
| LDP70_RS22985 (LDP70_22985) | 40892..41215 | - | 324 | WP_223163851.1 | LysM peptidoglycan-binding domain-containing protein | - |
| LDP70_RS22990 (LDP70_22990) | 41732..42217 | - | 486 | WP_000905606.1 | membrane protein | - |
| LDP70_RS22995 (LDP70_22995) | 42211..42699 | - | 489 | WP_001075507.1 | CaiF/GrlA family transcriptional regulator | - |
| LDP70_RS23000 (LDP70_23000) | 42724..43437 | - | 714 | WP_121212594.1 | EAL domain-containing protein | - |
| LDP70_RS23005 (LDP70_23005) | 43446..44228 | - | 783 | WP_000082169.1 | site-specific integrase | - |
| LDP70_RS23010 (LDP70_23010) | 44263..44784 | - | 522 | WP_000198608.1 | hypothetical protein | - |
| LDP70_RS23015 (LDP70_23015) | 44781..45071 | - | 291 | WP_001266176.1 | hypothetical protein | - |
| LDP70_RS23020 (LDP70_23020) | 45073..45378 | - | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| LDP70_RS23025 (LDP70_23025) | 45380..45598 | - | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| LDP70_RS23030 (LDP70_23030) | 46274..46795 | + | 522 | WP_077681952.1 | hypothetical protein | - |
| LDP70_RS23035 (LDP70_23035) | 46839..47267 | - | 429 | Protein_63 | hypothetical protein | - |
| LDP70_RS23040 (LDP70_23040) | 47279..47574 | + | 296 | Protein_64 | cytoplasmic protein | - |
| LDP70_RS23045 (LDP70_23045) | 48068..49057 | + | 990 | WP_000461382.1 | RepB family plasmid replication initiator protein | - |
| LDP70_RS23050 (LDP70_23050) | 49426..49545 | - | 120 | Protein_66 | recombinase | - |
| LDP70_RS23055 (LDP70_23055) | 49598..49984 | - | 387 | WP_000751876.1 | YgiW/YdeI family stress tolerance OB fold protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | rck / spvB / spvC / fdeC / pefB / pefA / pefC / pefD | 1..59372 | 59372 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11587.48 Da Isoelectric Point: 6.9787
>T218847 WP_001159863.1 NZ_CP084533:c45378-45073 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
Download Length: 306 bp
>T218847 NZ_CP116110:713601-713897 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8314.16 Da Isoelectric Point: 4.5203
>AT218847 WP_000813641.1 NZ_CP084533:c45598-45380 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
Download Length: 219 bp
>AT218847 NZ_CP116110:713899-714294 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | I3W3D5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656ICA6 |