Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4178932..4179713 Replicon chromosome
Accession NZ_CP084532
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain SE211

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag LDP70_RS20435 Protein ID WP_000626100.1
Coordinates 4178932..4179423 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LDP70_RS20440 Protein ID WP_001110452.1
Coordinates 4179420..4179713 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDP70_RS20400 (4174392) 4174392..4174739 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
LDP70_RS20405 (4174715) 4174715..4176418 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
LDP70_RS20410 (4176455) 4176455..4177030 + 576 WP_001188509.1 transcriptional regulator -
LDP70_RS20420 (4177301) 4177301..4177375 - 75 Protein_3993 helix-turn-helix domain-containing protein -
LDP70_RS20425 (4177755) 4177755..4177832 + 78 Protein_3994 porin family protein -
LDP70_RS20430 (4177932) 4177932..4178684 + 753 WP_000842433.1 non-specific acid phosphatase -
LDP70_RS20435 (4178932) 4178932..4179423 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
LDP70_RS20440 (4179420) 4179420..4179713 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LDP70_RS20445 (4180030) 4180030..4180251 + 222 WP_001576552.1 hypothetical protein -
LDP70_RS20450 (4180517) 4180517..4181392 + 876 WP_000921676.1 AraC family transcriptional regulator -
LDP70_RS20455 (4181389) 4181389..4181676 + 288 WP_001541332.1 transcriptional regulator RtsB -
LDP70_RS20460 (4181669) 4181669..4181977 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
LDP70_RS20465 (4181976) 4181976..4182224 + 249 Protein_4002 Ig-like domain-containing protein -
LDP70_RS20470 (4182336) 4182336..4182467 + 132 Protein_4003 hypothetical protein -
LDP70_RS20475 (4182761) 4182761..4183666 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T218844 WP_000626100.1 NZ_CP084532:c4179423-4178932 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T218844 NZ_CP116110:184282-184389 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT218844 WP_001110452.1 NZ_CP084532:c4179713-4179420 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT218844 NZ_CP116110:c184234-184168 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References