Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4072036..4072552 Replicon chromosome
Accession NZ_CP084532
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain SE211

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag LDP70_RS19860 Protein ID WP_000220582.1
Coordinates 4072036..4072320 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LDP70_RS19865 Protein ID WP_000212724.1
Coordinates 4072310..4072552 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDP70_RS19845 (4067247) 4067247..4068899 + 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -
LDP70_RS19850 (4069308) 4069308..4071446 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
LDP70_RS19855 (4071568) 4071568..4072032 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LDP70_RS19860 (4072036) 4072036..4072320 - 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDP70_RS19865 (4072310) 4072310..4072552 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LDP70_RS19870 (4072630) 4072630..4074543 - 1914 WP_001212142.1 BglG family transcription antiterminator -
LDP70_RS19875 (4074560) 4074560..4075300 - 741 WP_000779259.1 KDGP aldolase family protein -
LDP70_RS19880 (4075297) 4075297..4076415 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LDP70_RS19885 (4076399) 4076399..4077532 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T218843 WP_000220582.1 NZ_CP084532:c4072320-4072036 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T218843 NZ_CP116109:72959-73111 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT218843 WP_000212724.1 NZ_CP084532:c4072552-4072310 [Salmonella enterica subsp. enterica serovar Enteritidis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT218843 NZ_CP116109:c72904-72847 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References