Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4030911..4031461 Replicon chromosome
Accession NZ_CP084532
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain SE211

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag LDP70_RS19640 Protein ID WP_001199743.1
Coordinates 4030911..4031219 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag LDP70_RS19645 Protein ID WP_001118105.1
Coordinates 4031222..4031461 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDP70_RS19620 (4027485) 4027485..4028225 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
LDP70_RS19625 (4028347) 4028347..4028877 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
LDP70_RS19630 (4029200) 4029200..4030333 + 1134 Protein_3842 IS3 family transposase -
LDP70_RS19635 (4030365) 4030365..4030505 - 141 Protein_3843 Arm DNA-binding domain-containing protein -
LDP70_RS19640 (4030911) 4030911..4031219 - 309 WP_001199743.1 CcdB family protein Toxin
LDP70_RS19645 (4031222) 4031222..4031461 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LDP70_RS19650 (4031570) 4031570..4031818 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
LDP70_RS19655 (4032009) 4032009..4032440 - 432 Protein_3847 helix-turn-helix domain-containing protein -
LDP70_RS19670 (4033197) 4033197..4034216 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
LDP70_RS19675 (4034244) 4034244..4034774 - 531 WP_000896758.1 gluconokinase -
LDP70_RS19680 (4034991) 4034991..4036022 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4029292..4032395 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T218842 WP_001199743.1 NZ_CP084532:c4031219-4030911 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T218842 NZ_CP116108:169985-170401 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT218842 WP_001118105.1 NZ_CP084532:c4031461-4031222 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT218842 NZ_CP116108:169758-169988 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGAGCCGGACTTTATGACGGAGCGCAAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References