Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2771879..2772531 Replicon chromosome
Accession NC_008769
Organism Mycobacterium bovis BCG str. Pasteur 1173P2

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag BCG_RS12990 Protein ID WP_003412752.1
Coordinates 2772106..2772531 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag BCG_RS12985 Protein ID WP_003412749.1
Coordinates 2771879..2772100 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCG_RS12970 2770119..2770325 - 207 WP_003899347.1 hypothetical protein -
BCG_RS12975 2770461..2771084 + 624 WP_003900858.1 TIGR00725 family protein -
BCG_RS12980 2771074..2771826 + 753 WP_003901416.1 hypothetical protein -
BCG_RS12985 2771879..2772100 + 222 WP_003412749.1 antitoxin Antitoxin
BCG_RS12990 2772106..2772531 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
BCG_RS12995 2772554..2773735 - 1182 WP_010950729.1 2-oxo acid dehydrogenase subunit E2 -
BCG_RS13000 2773732..2774778 - 1047 WP_010950730.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
BCG_RS13005 2774789..2775892 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
BCG_RS13010 2776151..2776972 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
BCG_RS13015 2776969..2777526 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T21884 WP_003412752.1 NC_008769:2772106-2772531 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T21884 NC_008769:2772106-2772531 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGTGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT21884 WP_003412749.1 NC_008769:2771879-2772100 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT21884 NC_008769:2771879-2772100 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References