Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3411120..3411740 Replicon chromosome
Accession NZ_CP084532
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain SE211

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LDP70_RS16780 Protein ID WP_001280991.1
Coordinates 3411522..3411740 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LDP70_RS16775 Protein ID WP_000344807.1
Coordinates 3411120..3411494 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDP70_RS16765 (3406259) 3406259..3407452 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LDP70_RS16770 (3407475) 3407475..3410624 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LDP70_RS16775 (3411120) 3411120..3411494 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LDP70_RS16780 (3411522) 3411522..3411740 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LDP70_RS16785 (3411919) 3411919..3412470 + 552 WP_001278793.1 maltose O-acetyltransferase -
LDP70_RS16790 (3412588) 3412588..3413058 + 471 WP_000136183.1 YlaC family protein -
LDP70_RS16795 (3413114) 3413114..3413254 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LDP70_RS16800 (3413260) 3413260..3413520 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LDP70_RS16805 (3413745) 3413745..3415295 + 1551 WP_000213140.1 EAL domain-containing protein -
LDP70_RS16815 (3415526) 3415526..3415915 + 390 WP_000961287.1 MGMT family protein -
LDP70_RS16820 (3415948) 3415948..3416517 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T218837 WP_001280991.1 NZ_CP084532:3411522-3411740 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T218837 NZ_CP116108:c92379-92092 [Escherichia coli]
ATGACTTATACAGTAAAATTCAGGGATGATGCGCTCAAAGAATGGCTGAAACTGGATAAATCCATTCAACAGCAGTTTGC
GAAAAAACTAAAGAAATGCAGCGAAAATCCTCATATTCCTTCCGCAAAACTGCGTGGATTAAAAGACTGCTACAAAATCA
AACTTCGCGCATCGGGGTTTCGTCTGGTCTATCAGGTTATTGATGACATGCTAATTATTGCGGTTGTCGCGGTAGGTAAA
CGTGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT218837 WP_000344807.1 NZ_CP084532:3411120-3411494 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT218837 NZ_CP116108:c92627-92376 [Escherichia coli]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTATCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCGGAACTCTATGAAAGGATGC
TTGATGCGCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTGGAC
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References