21883

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2382203..2382732 Replicon chromosome
Accession NC_008769
Organism Mycobacterium bovis BCG str. Pasteur 1173P2

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag BCG_RS11135 Protein ID WP_003411124.1
Coordinates 2382203..2382520 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag BCG_RS11140 Protein ID WP_003411127.1
Coordinates 2382517..2382732 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCG_RS11105 2377340..2378416 + 1077 WP_003411110.1 hypothetical protein -
BCG_RS11110 2378413..2378694 + 282 WP_019283661.1 hypothetical protein -
BCG_RS11115 2378730..2379803 + 1074 WP_011799246.1 quinone-dependent dihydroorotate dehydrogenase -
BCG_RS11120 2379808..2380338 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
BCG_RS11125 2380386..2381732 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
BCG_RS11135 2382203..2382520 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BCG_RS11140 2382517..2382732 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
BCG_RS11145 2382987..2384045 + 1059 WP_003411129.1 hypothetical protein -
BCG_RS11150 2384175..2384531 - 357 WP_003411130.1 hypothetical protein -
BCG_RS11155 2384626..2385408 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
BCG_RS11160 2385676..2385966 - 291 WP_003900476.1 YggT family protein -
BCG_RS11165 2386128..2386784 - 657 WP_003411133.1 cell division protein SepF -
BCG_RS11170 2386850..2387626 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T21883 WP_003411124.1 NC_008769:c2382520-2382203 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T21883 NC_008769:c2382520-2382203 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
ATGACGCGTAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT21883 WP_003411127.1 NC_008769:c2382732-2382517 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT21883 NC_008769:c2382732-2382517 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References