Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 825023..825683 Replicon chromosome
Accession NZ_CP084532
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain SE211

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LDP70_RS03970 Protein ID WP_000244756.1
Coordinates 825270..825683 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LDP70_RS03965 Protein ID WP_000351186.1
Coordinates 825023..825289 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDP70_RS03945 (820952) 820952..822385 - 1434 WP_121212601.1 6-phospho-beta-glucosidase BglA -
LDP70_RS03950 (822543) 822543..822854 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LDP70_RS03955 (823018) 823018..823677 + 660 WP_000250289.1 hemolysin III family protein -
LDP70_RS03960 (823793) 823793..824773 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
LDP70_RS03965 (825023) 825023..825289 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LDP70_RS03970 (825270) 825270..825683 + 414 WP_000244756.1 protein YgfX Toxin
LDP70_RS03975 (825736) 825736..826257 - 522 WP_001055885.1 flavodoxin FldB -
LDP70_RS03980 (826370) 826370..827266 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LDP70_RS03985 (827290) 827290..828003 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LDP70_RS03990 (828009) 828009..829742 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T218824 WP_000244756.1 NZ_CP084532:825270-825683 [Salmonella enterica subsp. enterica serovar Enteritidis]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T218824 NZ_CP116106:1318433-1318831 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT218824 WP_000351186.1 NZ_CP084532:825023-825289 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT218824 NZ_CP116106:1318206-1318433 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References