Detailed information of TA system TA218820

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazF-pemI/MazF(toxin)
• Location: 999088..999722
• Replicon: chromosome
• Accession: NZ_CP084530
• Organism: Paenibacillus sp. YPG26

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: LDO05_RS04530
• Protein ID: WP_127199609.1
• Coordinates: 999372..999722 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: -
• Locus tag: LDO05_RS04525
• Protein ID: WP_276575549.1
• Coordinates: 999088..999369 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO05_RS04505 (LDO05_04530)	994482..995675	+	1194	WP_251378606.1	acyltransferase	-
LDO05_RS04510 (LDO05_04535)	995794..996051	+	258	WP_251377724.1	hypothetical protein	-
LDO05_RS04515 (LDO05_04540)	996277..997425	+	1149	WP_251377726.1	outer membrane lipoprotein-sorting protein	-
LDO05_RS04520 (LDO05_04545)	997659..998855	+	1197	WP_251377728.1	alanine racemase	-
LDO05_RS04525 (LDO05_04550)	999088..999369	+	282	WP_276575549.1	ribbon-helix-helix protein, CopG family	Antitoxin
LDO05_RS04530 (LDO05_04555)	999372..999722	+	351	WP_127199609.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
LDO05_RS04535 (LDO05_04560)	999863..1002073	+	2211	WP_276575550.1	Tex family protein	-
LDO05_RS04540 (LDO05_04565)	1002236..1002370	-	135	WP_251377729.1	cortex morphogenetic protein CmpA	-
LDO05_RS04545 (LDO05_04570)	1002442..1002801	-	360	WP_251377730.1	hydrolase/acyltransferase	-
LDO05_RS04550 (LDO05_04575)	1002890..1003351	+	462	WP_251377731.1	SprT family protein	-
LDO05_RS04555 (LDO05_04580)	1003415..1003660	+	246	WP_251377732.1	hypothetical protein	-
LDO05_RS04560 (LDO05_04585)	1003788..1004090	+	303	WP_251377733.1	antibiotic biosynthesis monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-109)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-46)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12807.79 Da
• Isoelectric Point: 5.1499

>T218820 WP_127199609.1 NZ_CP084530:999372-999722 [Paenibacillus sp. YPG26]
MIVKRGDVFFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIEAATHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEETMKKVDESLLISVGLIDF

Nucleotide

• Length: 351 bp

>T218820 NZ_CP116106:291647-292174 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10759.40 Da
• Isoelectric Point: 5.8649

>AT218820 WP_276575549.1 NZ_CP084530:999088-999369 [Paenibacillus sp. YPG26]
MANMQSTKRIMISLPDYLLQEVDGIVALENSNRSELIRQAMKLYLNERKKRYIRESMQRGYMEMAKINLTMASEAFHAEE
DADSTLDRLVSGV

Nucleotide

• Length: 282 bp

>AT218820 NZ_CP116106:291374-291640 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA