Detailed information of TA system TA218773

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 1422759..1423300
• Replicon: chromosome
• Accession: NZ_CP084528
• Organism: Kaistella sp. GW4-15

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LC814_RS06570
• Protein ID: WP_226063154.1
• Coordinates: 1423004..1423300 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: LC814_RS06565
• Protein ID: WP_226063153.1
• Coordinates: 1422759..1423007 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LC814_RS06540	1418354..1418827	+	474	WP_226063148.1	1,2-phenylacetyl-CoA epoxidase subunit PaaD	-
LC814_RS06545	1418909..1419706	+	798	WP_226063149.1	enoyl-CoA hydratase-related protein	-
LC814_RS06550	1419817..1420629	+	813	WP_226063150.1	GLPGLI family protein	-
LC814_RS06555	1420629..1421762	+	1134	WP_226063151.1	3-hydroxyacyl-CoA dehydrogenase NAD-binding domain-containing protein	-
LC814_RS06560	1422221..1422634	+	414	WP_226063152.1	hotdog fold thioesterase	-
LC814_RS06565	1422759..1423007	+	249	WP_226063153.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
LC814_RS06570	1423004..1423300	+	297	WP_226063154.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LC814_RS06575	1423619..1424131	+	513	WP_226063155.1	sigma-70 family RNA polymerase sigma factor	-
LC814_RS06580	1424144..1424818	+	675	WP_226063156.1	hypothetical protein	-
LC814_RS06585	1424830..1426092	+	1263	WP_226063157.1	DUF4252 domain-containing protein	-
LC814_RS06590	1426097..1426621	+	525	WP_226063158.1	DUF4252 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 12065.61 Da
• Isoelectric Point: 5.2333

>T218773 WP_226063154.1 NZ_CP084528:1423004-1423300 [Kaistella sp. GW4-15]
MIFEISEKANEDLENIWLYTYENWSQEQADRYYNLILNEIEYITENFESGKSFEHIRKGYRSAKVKSHLVFYRISKRDTI
EIIRILHQRMDIENRLVE

Nucleotide

• Length: 297 bp

>T218773 NZ_CP116100:335107-335209 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9380.84 Da
• Isoelectric Point: 10.0988

>AT218773 WP_226063153.1 NZ_CP084528:1422759-1423007 [Kaistella sp. GW4-15]
MGKNTSILLGDHFENFVNEKITSGKFSSVSEVIRNALRLMENEENKTKILINELKIGEKSGIVKDFDRNENLKKIHAKHL
VK

Nucleotide

• Length: 249 bp

>AT218773 NZ_CP116100:c335247-334979 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT