Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1933955..1934477 Replicon chromosome
Accession NZ_CP084524
Organism Edwardsiella ictaluri strain S97-773

Toxin (Protein)


Gene name relE Uniprot ID C5BBL4
Locus tag DB731_RS09080 Protein ID WP_015871319.1
Coordinates 1934196..1934477 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C5BBL3
Locus tag DB731_RS09075 Protein ID WP_015871318.1
Coordinates 1933955..1934206 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DB731_RS09045 (DB731_09030) 1929113..1929775 - 663 WP_015871312.1 hypothetical protein -
DB731_RS09050 (DB731_09035) 1929775..1930335 - 561 WP_226092333.1 hypothetical protein -
DB731_RS09055 (DB731_09040) 1930356..1930799 - 444 WP_015871314.1 hypothetical protein -
DB731_RS09060 (DB731_09045) 1930841..1931236 - 396 WP_015871315.1 hypothetical protein -
DB731_RS09065 (DB731_09050) 1931394..1932648 - 1255 Protein_1747 DUF4043 family protein -
DB731_RS09070 (DB731_09055) 1932666..1933667 - 1002 WP_015871317.1 hypothetical protein -
DB731_RS09075 (DB731_09060) 1933955..1934206 + 252 WP_015871318.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DB731_RS09080 (DB731_09065) 1934196..1934477 + 282 WP_015871319.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DB731_RS09085 (DB731_09070) 1934549..1936663 - 2115 WP_015871320.1 hypothetical protein -
DB731_RS09090 (DB731_09075) 1936660..1938321 - 1662 WP_050977403.1 terminase -
DB731_RS09095 (DB731_09080) 1938314..1939090 - 777 WP_015871322.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1905553..1974052 68499


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10783.62 Da        Isoelectric Point: 10.6993

>T218769 WP_015871319.1 NZ_CP084524:1934196-1934477 [Edwardsiella ictaluri]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Download         Length: 282 bp

>T218769 NZ_CP116096:40883-41035 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9155.24 Da        Isoelectric Point: 3.7550

>AT218769 WP_015871318.1 NZ_CP084524:1933955-1934206 [Edwardsiella ictaluri]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Download         Length: 252 bp

>AT218769 NZ_CP116096:c40831-40771 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C5BBL4

Antitoxin

Source ID Structure
AlphaFold DB C5BBL3

References