218767

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 867793..868456 Replicon chromosome
Accession NZ_CP084524
Organism Edwardsiella ictaluri strain S97-773

Toxin (Protein)


Gene name tad Uniprot ID C5B7U4
Locus tag DB731_RS04030 Protein ID WP_015870280.1
Coordinates 868112..868456 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag DB731_RS04025 Protein ID WP_015870279.1
Coordinates 867793..868110 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DB731_RS03980 (DB731_03965) 863123..863671 + 549 WP_015870271.1 YaeQ family protein -
DB731_RS03985 (DB731_03970) 863673..864089 + 417 WP_015870272.1 alternative ribosome rescue aminoacyl-tRNA hydrolase ArfB -
DB731_RS03990 (DB731_03975) 864186..864864 + 679 Protein_762 envelope stress response activation lipoprotein NlpE -
DB731_RS03995 (DB731_03980) 864886..865146 - 261 WP_015870274.1 YfhL family 4Fe-4S dicluster ferredoxin -
DB731_RS04000 (DB731_03985) 865751..866029 + 279 WP_133175613.1 hypothetical protein -
DB731_RS04010 (DB731_03995) 866974..867153 + 180 WP_071525714.1 hypothetical protein -
DB731_RS04015 867258..867386 + 129 WP_015870277.1 hypothetical protein -
DB731_RS04020 (DB731_04000) 867383..867760 + 378 WP_015870278.1 type II toxin-antitoxin system death-on-curing family toxin -
DB731_RS04025 (DB731_04005) 867793..868110 - 318 WP_015870279.1 helix-turn-helix transcriptional regulator Antitoxin
DB731_RS04030 (DB731_04010) 868112..868456 - 345 WP_015870280.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DB731_RS04035 (DB731_04015) 868628..868846 - 219 WP_232347353.1 head completion/stabilization protein -
DB731_RS04040 (DB731_04020) 868875..869564 + 690 WP_015870281.1 phage portal protein -
DB731_RS04045 (DB731_04025) 870692..871539 - 848 Protein_773 MurR/RpiR family transcriptional regulator -
DB731_RS04050 (DB731_04030) 871695..872339 + 645 WP_226092411.1 phosphatidylglycerophosphatase C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-86)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12544.34 Da        Isoelectric Point: 9.8474

>T218767 WP_015870280.1 NZ_CP084524:c868456-868112 [Edwardsiella ictaluri]
MKSLYWVGSTKKDLQSLPEEVQDIFGYALHLAQVGGKHSQTKPLKGFSGAGVLEVVEDFLGDTYRAVYTVKFGDAVYVSH
VFQKKSSSGIATPKLNMDKIRERLKAAENHARGA

Download         Length: 345 bp

>T218767 NZ_CP116095:c40880-40731 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11480.41 Da        Isoelectric Point: 10.2058

>AT218767 WP_015870279.1 NZ_CP084524:c868110-867793 [Edwardsiella ictaluri]
MSHDIEVSSGNVYVDIGRDDAEEMLLKAQLATTIGNIIKSRSLTQEQAAKLLGMTQPKLSNMLRGQFRGISEAKMLECLT
RLGRDVQIVVGKPRRTPGSVKVVLA

Download         Length: 318 bp

>AT218767 NZ_CP116095:40924-40985 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C5B7U4

Antitoxin

Source ID Structure

References