Detailed information of TA system TA218765

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3246703..3247366
• Replicon: chromosome
• Accession: NZ_CP084521
• Organism: Edwardsiella ictaluri strain S07-698

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: C5BAS3
• Locus tag: DB741_RS15380
• Protein ID: WP_015872556.1
• Coordinates: 3246703..3247119 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: C5BAS4
• Locus tag: DB741_RS15385
• Protein ID: WP_015872557.1
• Coordinates: 3247100..3247366 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DB741_RS15360 (DB741_15350)	3242627..3244360	-	1734	WP_015872552.1	single-stranded-DNA-specific exonuclease RecJ	-
DB741_RS15365 (DB741_15355)	3244365..3245081	-	717	WP_015872553.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
DB741_RS15370 (DB741_15360)	3245109..3246008	-	900	WP_015872554.1	site-specific tyrosine recombinase XerD	-
DB741_RS15375 (DB741_15365)	3246166..3246678	+	513	WP_015872555.1	flavodoxin FldB	-
DB741_RS15380 (DB741_15370)	3246703..3247119	-	417	WP_015872556.1	protein YgfX	Toxin
DB741_RS15385 (DB741_15375)	3247100..3247366	-	267	WP_015872557.1	FAD assembly factor SdhE	Antitoxin
DB741_RS15390 (DB741_15380)	3247714..3248709	+	996	WP_015872558.1	tRNA-modifying protein YgfZ	-
DB741_RS15395 (DB741_15385)	3248750..3249574	-	825	WP_015872559.1	shikimate 5-dehydrogenase	-
DB741_RS15400 (DB741_15390)	3249736..3250608	-	873	WP_015872560.1	nucleoside-specific channel-forming protein Tsx	-
DB741_RS15405 (DB741_15395)	3251217..3251867	+	651	WP_035609190.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16145.89 Da
• Isoelectric Point: 11.3233

>T218765 WP_015872556.1 NZ_CP084521:c3247119-3246703 [Edwardsiella ictaluri]
VALWRCNVHASWRTQVMFLLGHGALVLAILLAPWPENYSVFWLILLVAVIFECIRSQRLIARNSGELQRLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGTPCRRRLWLAADSMSREEWGQLRRALLDTGDDRV

Nucleotide

• Length: 417 bp

>T218765 NZ_CP116094:4103393-4103857 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10364.92 Da
• Isoelectric Point: 5.6951

>AT218765 WP_015872557.1 NZ_CP084521:c3247366-3247100 [Edwardsiella ictaluri]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLSCDDPELFKWLMNQGKPDDTDLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT218765 NZ_CP116094:4103058-4103393 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: C5BAS3

Antitoxin

• AlphaFold DB: C5BAS4