Detailed information of TA system TA218763

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1937159..1937681
• Replicon: chromosome
• Accession: NZ_CP084521
• Organism: Edwardsiella ictaluri strain S07-698

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C5BBL4
• Locus tag: DB741_RS09105
• Protein ID: WP_015871319.1
• Coordinates: 1937400..1937681 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C5BBL3
• Locus tag: DB741_RS09100
• Protein ID: WP_015871318.1
• Coordinates: 1937159..1937410 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DB741_RS09070 (DB741_09070)	1932315..1932977	-	663	WP_015871312.1	hypothetical protein	-
DB741_RS09075 (DB741_09075)	1932977..1933537	-	561	WP_226092333.1	hypothetical protein	-
DB741_RS09080 (DB741_09080)	1933558..1934001	-	444	WP_015871314.1	hypothetical protein	-
DB741_RS09085 (DB741_09085)	1934043..1934438	-	396	WP_015871315.1	hypothetical protein	-
DB741_RS09090 (DB741_09090)	1934596..1935852	-	1257	WP_015871316.1	N4-gp56 family major capsid protein	-
DB741_RS09095 (DB741_09095)	1935870..1936871	-	1002	WP_107775275.1	hypothetical protein	-
DB741_RS09100 (DB741_09100)	1937159..1937410	+	252	WP_015871318.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DB741_RS09105 (DB741_09105)	1937400..1937681	+	282	WP_015871319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DB741_RS09110 (DB741_09110)	1937753..1939867	-	2115	WP_015871320.1	hypothetical protein	-
DB741_RS09115 (DB741_09115)	1939864..1941525	-	1662	WP_050977403.1	terminase	-
DB741_RS09120 (DB741_09120)	1941518..1942294	-	777	WP_015871322.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1908871..1972960	64089

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10783.62 Da
• Isoelectric Point: 10.6993

>T218763 WP_015871319.1 NZ_CP084521:1937400-1937681 [Edwardsiella ictaluri]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Nucleotide

• Length: 282 bp

>T218763 NZ_CP116094:c3993030-3992734 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9155.24 Da
• Isoelectric Point: 3.7550

>AT218763 WP_015871318.1 NZ_CP084521:1937159-1937410 [Edwardsiella ictaluri]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Nucleotide

• Length: 252 bp

>AT218763 NZ_CP116094:c3992732-3992337 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Structures

Toxin

• AlphaFold DB: C5BBL4

Antitoxin

• AlphaFold DB: C5BBL3