Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 3210422..3212142 Replicon chromosome
Accession NZ_CP084514
Organism Edwardsiella piscicida strain LADL97-168

Toxin (Protein)


Gene name pmenT Uniprot ID A0A411H3H5
Locus tag DCE53_RS14580 Protein ID WP_015683486.1
Coordinates 3211486..3212142 (-) Length 219 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag DCE53_RS14575 Protein ID WP_226081859.1
Coordinates 3210422..3211450 (-) Length 343 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCE53_RS14565 (DCE53_14565) 3206447..3207163 - 717 WP_012849890.1 SprT family zinc-dependent metalloprotease -
DCE53_RS14570 (DCE53_14570) 3207163..3210258 - 3096 WP_109745947.1 HsdR family type I site-specific deoxyribonuclease -
DCE53_RS14575 (DCE53_14575) 3210422..3211450 - 1029 WP_226081859.1 macro domain-containing protein Antitoxin
DCE53_RS14580 (DCE53_14580) 3211486..3212142 - 657 WP_015683486.1 DUF4433 domain-containing protein Toxin
DCE53_RS14585 (DCE53_14585) 3212155..3213504 - 1350 WP_080545142.1 restriction endonuclease subunit S -
DCE53_RS14590 (DCE53_14590) 3213516..3215954 - 2439 WP_015683488.1 type I restriction-modification system subunit M -
DCE53_RS14595 (DCE53_14595) 3215993..3216232 - 240 WP_012849883.1 hypothetical protein -
DCE53_RS14600 (DCE53_14600) 3216584..3216940 - 357 Protein_2814 integrase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(17-217)

Antitoxin

(5-116)


Sequences


Toxin        


Download         Length: 219 a.a.        Molecular weight: 25046.43 Da        Isoelectric Point: 6.9045

>T218760 WP_015683486.1 NZ_CP084514:c3212142-3211486 [Edwardsiella piscicida]
MAYDYSASLNPQKALIWRIVHRDNIPWILDNGLHCGNSQVQAVNWINIGNPELIGKRAGHPVPVGTGGTLHDYVPFYFTP
FSPMLMNIHSGRGGITQRPNEEIVILVSSLRSVAAQNAPFVFTDSHAYYNWANYYTRLEDLNQIDWSILQARDFRRDPDD
PAKFERYQAEALIWQHCPITLLVGMICYNDGVRLQLEQWLSQRNLTMPVHARAGWYFS

Download         Length: 657 bp

>T218760 NZ_CP116094:c3658115-3657780 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 343 a.a.        Molecular weight: 39249.39 Da        Isoelectric Point: 7.1506

>AT218760 WP_226081859.1 NZ_CP084514:c3211450-3210422 [Edwardsiella piscicida]
VEALVNTVNTVGVMGKGIALMFKERFPDNMKAYAHACKQKQVMTGKMFITETGELMGPRWIVNFPTKQHWRADSRMAWIE
DGLQDLRRFLIEKKVRSIAIPPLGAGNGGLNWPDVRARIESALGDLQDTEILIYEPTEKYQNVAKSSGVKKLTPARAMIA
ELVRRYWVLGMECSLLEIQKLAWLLQRAIELHQQEDVLKLRFEAHYYGPYAPNLNHLLNALDGTYLKAEKRIPDSQPLDV
IWFNDREKEHINLWLNSEAKAWLPALEQVSQLIDGFESPFGLELLATVDWLLTRGQCQPTLDSVKEGLHQWPAGEPWASR
KIKLFDDKNLQFAINRVMEFHC

Download         Length: 1029 bp

>AT218760 NZ_CP116094:c3658363-3658115 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A411H3H5


Antitoxin

Source ID Structure

References