Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3081187..3081850 Replicon chromosome
Accession NZ_CP084514
Organism Edwardsiella piscicida strain LADL97-168

Toxin (Protein)


Gene name cptA Uniprot ID A0A411H3S7
Locus tag DCE53_RS14025 Protein ID WP_034167931.1
Coordinates 3081187..3081603 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D0ZDY6
Locus tag DCE53_RS14030 Protein ID WP_012849755.1
Coordinates 3081584..3081850 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCE53_RS14005 (DCE53_14005) 3077118..3078851 - 1734 WP_012849750.1 single-stranded-DNA-specific exonuclease RecJ -
DCE53_RS14010 (DCE53_14010) 3078856..3079572 - 717 WP_012849751.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DCE53_RS14015 (DCE53_14015) 3079600..3080499 - 900 WP_012849752.1 site-specific tyrosine recombinase XerD -
DCE53_RS14020 (DCE53_14020) 3080650..3081162 + 513 WP_012849753.1 flavodoxin FldB -
DCE53_RS14025 (DCE53_14025) 3081187..3081603 - 417 WP_034167931.1 protein YgfX Toxin
DCE53_RS14030 (DCE53_14030) 3081584..3081850 - 267 WP_012849755.1 FAD assembly factor SdhE Antitoxin
DCE53_RS14035 (DCE53_14035) 3082204..3083202 + 999 WP_012849756.1 tRNA-modifying protein YgfZ -
DCE53_RS14040 (DCE53_14040) 3083245..3084069 - 825 WP_109745894.1 shikimate 5-dehydrogenase -
DCE53_RS14045 (DCE53_14045) 3084228..3085100 - 873 WP_012849758.1 nucleoside-specific channel-forming protein Tsx -
DCE53_RS14050 (DCE53_14050) 3085709..3086359 + 651 WP_015462279.1 hemolysin III family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16213.03 Da        Isoelectric Point: 11.6049

>T218759 WP_034167931.1 NZ_CP084514:c3081603-3081187 [Edwardsiella piscicida]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSVFWLILLVAVIFECIRSQRRIARNRGELQLLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGAPCRRRLWLAADSMSREEWGQLRRTLLDAGDDRA

Download         Length: 417 bp

>T218759 NZ_CP116094:c2884491-2884240 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10318.90 Da        Isoelectric Point: 5.6951

>AT218759 WP_012849755.1 NZ_CP084514:c3081850-3081584 [Edwardsiella piscicida]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Download         Length: 267 bp

>AT218759 NZ_CP116094:c2884243-2883989 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411H3S7

Antitoxin

Source ID Structure
AlphaFold DB A0A034T2Q8

References