Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1092917..1093509 Replicon chromosome
Accession NZ_CP084514
Organism Edwardsiella piscicida strain LADL97-168

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag DCE53_RS04865 Protein ID WP_012847872.1
Coordinates 1092917..1093120 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A411GZW1
Locus tag DCE53_RS04870 Protein ID WP_015461125.1
Coordinates 1093141..1093509 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCE53_RS04835 (DCE53_04835) 1088621..1089082 + 462 WP_012847865.1 Lrp/AsnC family transcriptional regulator -
DCE53_RS04840 (DCE53_04840) 1089387..1089725 + 339 WP_012847867.1 P-II family nitrogen regulator -
DCE53_RS04845 (DCE53_04845) 1089747..1091027 + 1281 WP_041692495.1 ammonium transporter AmtB -
DCE53_RS04850 (DCE53_04850) 1091062..1091928 - 867 WP_012847869.1 acyl-CoA thioesterase II -
DCE53_RS04855 (DCE53_04855) 1092037..1092366 - 330 WP_225857588.1 MGMT family protein -
DCE53_RS04865 (DCE53_04865) 1092917..1093120 - 204 WP_012847872.1 HHA domain-containing protein Toxin
DCE53_RS04870 (DCE53_04870) 1093141..1093509 - 369 WP_015461125.1 Hha toxicity modulator TomB Antitoxin
DCE53_RS04875 (DCE53_04875) 1093878..1097030 - 3153 WP_012847874.1 efflux RND transporter permease subunit -
DCE53_RS04880 (DCE53_04880) 1097074..1098258 - 1185 WP_034168424.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T218757 WP_012847872.1 NZ_CP084514:c1093120-1092917 [Edwardsiella piscicida]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T218757 NZ_CP116094:2871023-2871397 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACTCCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATTCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14099.80 Da        Isoelectric Point: 6.1484

>AT218757 WP_015461125.1 NZ_CP084514:c1093509-1093141 [Edwardsiella piscicida]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPHHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT218757 NZ_CP116094:2870566-2870934 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACTCATCCCGATGACAACAACAGCCACCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTATCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB A0A411GZW1

References