Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 135689..136236 Replicon plasmid pIncFIBK_IncFII
Accession NZ_CP084503
Organism Klebsiella pneumoniae strain MI01_K

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag KRU50_RS26080 Protein ID WP_001384452.1
Coordinates 135689..135967 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1M1SX19
Locus tag KRU50_RS26085 Protein ID WP_021546940.1
Coordinates 135967..136236 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KRU50_RS26055 (KRU50_26080) 131383..132192 - 810 WP_000161640.1 hypothetical protein -
KRU50_RS26060 (KRU50_26085) 132538..133242 + 705 WP_001067852.1 IS6-like element IS26 family transposase -
KRU50_RS26065 (KRU50_26090) 133297..134847 + 1551 Protein_146 Tn3-like element TnAs1 family transposase -
KRU50_RS26070 (KRU50_26095) 135100..135336 - 237 WP_223417154.1 transposase -
KRU50_RS26075 (KRU50_26100) 135431..135643 - 213 Protein_148 3'-5' exonuclease -
KRU50_RS26080 (KRU50_26105) 135689..135967 - 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
KRU50_RS26085 (KRU50_26110) 135967..136236 - 270 WP_021546940.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
KRU50_RS26090 (KRU50_26115) 137144..138157 - 1014 WP_016831068.1 plasmid replication initiator RepA -
KRU50_RS26095 (KRU50_26125) 138342..138516 - 175 Protein_152 protein CopA/IncA -
KRU50_RS26100 (KRU50_26130) 138599..138868 - 270 WP_016831067.1 replication regulatory protein RepA -
KRU50_RS26105 (KRU50_26135) 139004..139555 - 552 WP_032433753.1 phospholipase D family protein -
KRU50_RS26110 (KRU50_26140) 139659..139967 - 309 WP_016831065.1 hypothetical protein -
KRU50_RS26115 (KRU50_26145) 139964..140614 - 651 WP_117272854.1 DUF2726 domain-containing protein -
KRU50_RS26120 (KRU50_26150) 140670..140891 - 222 WP_016831063.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / blaCTX-M-15 / qnrS1 - 1..251955 251955


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T218740 WP_001384452.1 NZ_CP084503:c135967-135689 [Klebsiella pneumoniae]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

>T218740 NZ_CP116089:12469-12885 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10321.69 Da        Isoelectric Point: 8.8725

>AT218740 WP_021546940.1 NZ_CP084503:c136236-135967 [Klebsiella pneumoniae]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSAAAWRD
EMRRKVADK

Download         Length: 270 bp

>AT218740 NZ_CP116089:12242-12472 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1SX19

References