Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4687008..4687524 Replicon chromosome
Accession NZ_CP084502
Organism Klebsiella pneumoniae strain MI01_K

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KRU50_RS22700 Protein ID WP_002886902.1
Coordinates 4687008..4687292 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KRU50_RS22705 Protein ID WP_002886901.1
Coordinates 4687282..4687524 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KRU50_RS22675 (4682425) 4682425..4682688 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
KRU50_RS22680 (4682818) 4682818..4682991 + 174 WP_032410138.1 hypothetical protein -
KRU50_RS22685 (4682994) 4682994..4683737 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
KRU50_RS22690 (4684094) 4684094..4686232 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KRU50_RS22695 (4686540) 4686540..4687004 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KRU50_RS22700 (4687008) 4687008..4687292 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KRU50_RS22705 (4687282) 4687282..4687524 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KRU50_RS22710 (4687602) 4687602..4689512 - 1911 WP_004152270.1 PRD domain-containing protein -
KRU50_RS22715 (4689535) 4689535..4690689 - 1155 WP_002886900.1 lactonase family protein -
KRU50_RS22720 (4690756) 4690756..4691496 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T218736 WP_002886902.1 NZ_CP084502:c4687292-4687008 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T218736 NZ_CP116088:c4167710-4167432 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAAGTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT218736 WP_002886901.1 NZ_CP084502:c4687524-4687282 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT218736 NZ_CP116088:c4167973-4167713 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References